Tracing environmental markers of autoimmunity

Introducing the infectome

Dimitrios P. Bogdanos, Daniel S. Smyk, Pietro Invernizzi, Eirini I. Rigopoulou, Miri Blank, Lazaros Sakkas, Shideh Pouria, Yehuda Shoenfeld

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

We recently introduced the concept of the infectome as a means of studying all infectious factors which contribute to the development of autoimmune disease. It forms the infectious part of the exposome, which collates all environmental factors contributing to the development of disease and studies the sum total of burden which leads to the loss of adaptive mechanisms in the body. These studies complement genome-wide association studies, which establish the genetic predisposition to disease. The infectome is a component which spans the whole life and may begin at the earliest stages right up to the time when the first symptoms manifest, and may thus contribute to the understanding of the pathogenesis of autoimmunity at the prodromal/asymptomatic stages. We provide practical examples and research tools as to how we can investigate disease-specific infectomes, using laboratory approaches employed from projects studying the "immunome" and "microbiome". It is envisioned that an understanding of the infectome and the environmental factors that affect it will allow for earlier patient-specific intervention by clinicians, through the possible treatment of infectious agents as well as other compounding factors, and hence slowing or preventing disease development.

Original languageEnglish (US)
Pages (from-to)220-240
Number of pages21
JournalImmunologic Research
Volume56
Issue number2-3
DOIs
StatePublished - Jul 2013
Externally publishedYes

Fingerprint

Autoimmunity
Prodromal Symptoms
Genome-Wide Association Study
Microbiota
Genetic Predisposition to Disease
Autoimmune Diseases
Research
Therapeutics

Keywords

  • Autoimmune disease
  • Autoimmunity
  • Environment
  • Immunity
  • Infection
  • Microbiome

ASJC Scopus subject areas

  • Immunology

Cite this

Bogdanos, D. P., Smyk, D. S., Invernizzi, P., Rigopoulou, E. I., Blank, M., Sakkas, L., ... Shoenfeld, Y. (2013). Tracing environmental markers of autoimmunity: Introducing the infectome. Immunologic Research, 56(2-3), 220-240. https://doi.org/10.1007/s12026-013-8399-6

Tracing environmental markers of autoimmunity : Introducing the infectome. / Bogdanos, Dimitrios P.; Smyk, Daniel S.; Invernizzi, Pietro; Rigopoulou, Eirini I.; Blank, Miri; Sakkas, Lazaros; Pouria, Shideh; Shoenfeld, Yehuda.

In: Immunologic Research, Vol. 56, No. 2-3, 07.2013, p. 220-240.

Research output: Contribution to journalArticle

Bogdanos, DP, Smyk, DS, Invernizzi, P, Rigopoulou, EI, Blank, M, Sakkas, L, Pouria, S & Shoenfeld, Y 2013, 'Tracing environmental markers of autoimmunity: Introducing the infectome', Immunologic Research, vol. 56, no. 2-3, pp. 220-240. https://doi.org/10.1007/s12026-013-8399-6
Bogdanos DP, Smyk DS, Invernizzi P, Rigopoulou EI, Blank M, Sakkas L et al. Tracing environmental markers of autoimmunity: Introducing the infectome. Immunologic Research. 2013 Jul;56(2-3):220-240. https://doi.org/10.1007/s12026-013-8399-6
Bogdanos, Dimitrios P. ; Smyk, Daniel S. ; Invernizzi, Pietro ; Rigopoulou, Eirini I. ; Blank, Miri ; Sakkas, Lazaros ; Pouria, Shideh ; Shoenfeld, Yehuda. / Tracing environmental markers of autoimmunity : Introducing the infectome. In: Immunologic Research. 2013 ; Vol. 56, No. 2-3. pp. 220-240.
@article{78422d8d2cbb4e10adaeedc9fd5679f0,
title = "Tracing environmental markers of autoimmunity: Introducing the infectome",
abstract = "We recently introduced the concept of the infectome as a means of studying all infectious factors which contribute to the development of autoimmune disease. It forms the infectious part of the exposome, which collates all environmental factors contributing to the development of disease and studies the sum total of burden which leads to the loss of adaptive mechanisms in the body. These studies complement genome-wide association studies, which establish the genetic predisposition to disease. The infectome is a component which spans the whole life and may begin at the earliest stages right up to the time when the first symptoms manifest, and may thus contribute to the understanding of the pathogenesis of autoimmunity at the prodromal/asymptomatic stages. We provide practical examples and research tools as to how we can investigate disease-specific infectomes, using laboratory approaches employed from projects studying the {"}immunome{"} and {"}microbiome{"}. It is envisioned that an understanding of the infectome and the environmental factors that affect it will allow for earlier patient-specific intervention by clinicians, through the possible treatment of infectious agents as well as other compounding factors, and hence slowing or preventing disease development.",
keywords = "Autoimmune disease, Autoimmunity, Environment, Immunity, Infection, Microbiome",
author = "Bogdanos, {Dimitrios P.} and Smyk, {Daniel S.} and Pietro Invernizzi and Rigopoulou, {Eirini I.} and Miri Blank and Lazaros Sakkas and Shideh Pouria and Yehuda Shoenfeld",
year = "2013",
month = "7",
doi = "10.1007/s12026-013-8399-6",
language = "English (US)",
volume = "56",
pages = "220--240",
journal = "Immunologic Research",
issn = "0257-277X",
publisher = "Humana Press",
number = "2-3",

}

TY - JOUR

T1 - Tracing environmental markers of autoimmunity

T2 - Introducing the infectome

AU - Bogdanos, Dimitrios P.

AU - Smyk, Daniel S.

AU - Invernizzi, Pietro

AU - Rigopoulou, Eirini I.

AU - Blank, Miri

AU - Sakkas, Lazaros

AU - Pouria, Shideh

AU - Shoenfeld, Yehuda

PY - 2013/7

Y1 - 2013/7

N2 - We recently introduced the concept of the infectome as a means of studying all infectious factors which contribute to the development of autoimmune disease. It forms the infectious part of the exposome, which collates all environmental factors contributing to the development of disease and studies the sum total of burden which leads to the loss of adaptive mechanisms in the body. These studies complement genome-wide association studies, which establish the genetic predisposition to disease. The infectome is a component which spans the whole life and may begin at the earliest stages right up to the time when the first symptoms manifest, and may thus contribute to the understanding of the pathogenesis of autoimmunity at the prodromal/asymptomatic stages. We provide practical examples and research tools as to how we can investigate disease-specific infectomes, using laboratory approaches employed from projects studying the "immunome" and "microbiome". It is envisioned that an understanding of the infectome and the environmental factors that affect it will allow for earlier patient-specific intervention by clinicians, through the possible treatment of infectious agents as well as other compounding factors, and hence slowing or preventing disease development.

AB - We recently introduced the concept of the infectome as a means of studying all infectious factors which contribute to the development of autoimmune disease. It forms the infectious part of the exposome, which collates all environmental factors contributing to the development of disease and studies the sum total of burden which leads to the loss of adaptive mechanisms in the body. These studies complement genome-wide association studies, which establish the genetic predisposition to disease. The infectome is a component which spans the whole life and may begin at the earliest stages right up to the time when the first symptoms manifest, and may thus contribute to the understanding of the pathogenesis of autoimmunity at the prodromal/asymptomatic stages. We provide practical examples and research tools as to how we can investigate disease-specific infectomes, using laboratory approaches employed from projects studying the "immunome" and "microbiome". It is envisioned that an understanding of the infectome and the environmental factors that affect it will allow for earlier patient-specific intervention by clinicians, through the possible treatment of infectious agents as well as other compounding factors, and hence slowing or preventing disease development.

KW - Autoimmune disease

KW - Autoimmunity

KW - Environment

KW - Immunity

KW - Infection

KW - Microbiome

UR - http://www.scopus.com/inward/record.url?scp=84879552408&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879552408&partnerID=8YFLogxK

U2 - 10.1007/s12026-013-8399-6

DO - 10.1007/s12026-013-8399-6

M3 - Article

VL - 56

SP - 220

EP - 240

JO - Immunologic Research

JF - Immunologic Research

SN - 0257-277X

IS - 2-3

ER -