Abstract
Today, tracheal lesions occupying<30% of the trachea in children and<50% in adults can be treated with primary resection, followed by end-to-end anastomosis. However, lesions larger than this require a tracheal replacement, of which there are currently few options available. The recent advancement of tissue-engineering principles in tracheal research is quickly opening up new vistas for airway reconstruction and creating a very promising future for medical science. This review discusses the main criteria required for the development of a tissue-engineered tracheal replacement. The criteria include: (a) appropriate cell types and sources; (b) biomolecules to direct the differentiation of the cells to the desired lineage (c) a suitable scaffold for a cellular matrix; and (d) a bioreactor to facilitate cell attachment and proliferation and construct transport to theatre. Our group has designed and developed the world's first synthetic tracheal replacement, using a novel nanocomposite material, also developed in our laboratory. It was implanted clinically in June 2011 with a successful outcome. The application of tissue-engineering approaches to tracheal replacement development is the first step towards the much-anticipated 'off-the-shelf' tissue-engineered technology, contributing extensively to the advancement in treatment and rehabilitation of patients afflicted with tracheal pathology.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 357-367 |
| Number of pages | 11 |
| Journal | Journal of Tissue Engineering and Regenerative Medicine |
| Volume | 9 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1 2015 |
| Externally published | Yes |
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Keywords
- Biomaterials
- Cartilage
- Clinical study
- Nanocomposite
- Nanotechnology
- POSS-PCU
- Regenerative medicine
- Stem cells
- Tissue engineering
- Trachea
- Transplantation
ASJC Scopus subject areas
- Biomedical Engineering
- Medicine (miscellaneous)
- Biomaterials
Cite this
Trachea transplantation : From laboratory to patient. / Crowley, Claire; Birchall, Martin; Seifalian, Alexander M.
In: Journal of Tissue Engineering and Regenerative Medicine, Vol. 9, No. 4, 01.04.2015, p. 357-367.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Trachea transplantation
T2 - From laboratory to patient
AU - Crowley, Claire
AU - Birchall, Martin
AU - Seifalian, Alexander M.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Today, tracheal lesions occupying<30% of the trachea in children and<50% in adults can be treated with primary resection, followed by end-to-end anastomosis. However, lesions larger than this require a tracheal replacement, of which there are currently few options available. The recent advancement of tissue-engineering principles in tracheal research is quickly opening up new vistas for airway reconstruction and creating a very promising future for medical science. This review discusses the main criteria required for the development of a tissue-engineered tracheal replacement. The criteria include: (a) appropriate cell types and sources; (b) biomolecules to direct the differentiation of the cells to the desired lineage (c) a suitable scaffold for a cellular matrix; and (d) a bioreactor to facilitate cell attachment and proliferation and construct transport to theatre. Our group has designed and developed the world's first synthetic tracheal replacement, using a novel nanocomposite material, also developed in our laboratory. It was implanted clinically in June 2011 with a successful outcome. The application of tissue-engineering approaches to tracheal replacement development is the first step towards the much-anticipated 'off-the-shelf' tissue-engineered technology, contributing extensively to the advancement in treatment and rehabilitation of patients afflicted with tracheal pathology.
AB - Today, tracheal lesions occupying<30% of the trachea in children and<50% in adults can be treated with primary resection, followed by end-to-end anastomosis. However, lesions larger than this require a tracheal replacement, of which there are currently few options available. The recent advancement of tissue-engineering principles in tracheal research is quickly opening up new vistas for airway reconstruction and creating a very promising future for medical science. This review discusses the main criteria required for the development of a tissue-engineered tracheal replacement. The criteria include: (a) appropriate cell types and sources; (b) biomolecules to direct the differentiation of the cells to the desired lineage (c) a suitable scaffold for a cellular matrix; and (d) a bioreactor to facilitate cell attachment and proliferation and construct transport to theatre. Our group has designed and developed the world's first synthetic tracheal replacement, using a novel nanocomposite material, also developed in our laboratory. It was implanted clinically in June 2011 with a successful outcome. The application of tissue-engineering approaches to tracheal replacement development is the first step towards the much-anticipated 'off-the-shelf' tissue-engineered technology, contributing extensively to the advancement in treatment and rehabilitation of patients afflicted with tracheal pathology.
KW - Biomaterials
KW - Cartilage
KW - Clinical study
KW - Nanocomposite
KW - Nanotechnology
KW - POSS-PCU
KW - Regenerative medicine
KW - Stem cells
KW - Tissue engineering
KW - Trachea
KW - Transplantation
UR - http://www.scopus.com/inward/record.url?scp=84927690739&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84927690739&partnerID=8YFLogxK
U2 - 10.1002/term.1847
DO - 10.1002/term.1847
M3 - Article
C2 - 26052583
AN - SCOPUS:84927690739
VL - 9
SP - 357
EP - 367
JO - Journal of Tissue Engineering and Regenerative Medicine
JF - Journal of Tissue Engineering and Regenerative Medicine
SN - 1932-6254
IS - 4
ER -