Trace element transport in the mammary gland

Bo Lönnerdal

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

The mammary gland has a remarkable capacity to adapt to maternal deficiency or excess of iron, copper, and zinc and to homeostatically control milk concentrations of these essential nutrients. Similarly, it can regulate changes in concentrations of iron, copper, and zinc change during lactation. For iron, this regulation is achieved by transferrin receptor, DMT1, and ferroportin, whereas mammary gland copper metabolism is regulated by Ctr1, ATP7A, and ATP7B. Zinc homeostasis is complex, involving both zinc importers (Zip3) and zinc exporters (ZnT-1, ZnT-2, and ZnT-4). Both transcriptional and post-translational regulation can affect protein abundance and cellular localization of these transporters, finely orchestrating uptake, intracellular trafficking, and secretion of iron, copper, and zinc. The control of mammary gland uptake and milk secretion of iron, copper, and zinc protects both the mammary gland and the breast-fed infant against deficiency and excess of these nutrients.

Original languageEnglish (US)
Pages (from-to)165-177
Number of pages13
JournalAnnual Review of Nutrition
Volume27
DOIs
StatePublished - 2007

Fingerprint

Trace Elements
Human Mammary Glands
Zinc
Copper
Iron
Food
Transferrin Receptors
Human Milk
Lactation
Milk
Breast
Homeostasis
Mothers
Proteins

Keywords

  • Copper
  • Copper transporters
  • Interactions
  • Iron
  • Iron transporters
  • Vitamin A
  • Zinc
  • Zinc transporters

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Trace element transport in the mammary gland. / Lönnerdal, Bo.

In: Annual Review of Nutrition, Vol. 27, 2007, p. 165-177.

Research output: Contribution to journalArticle

Lönnerdal, Bo. / Trace element transport in the mammary gland. In: Annual Review of Nutrition. 2007 ; Vol. 27. pp. 165-177.
@article{25cd1b3cac89450ca46a0f8611719a35,
title = "Trace element transport in the mammary gland",
abstract = "The mammary gland has a remarkable capacity to adapt to maternal deficiency or excess of iron, copper, and zinc and to homeostatically control milk concentrations of these essential nutrients. Similarly, it can regulate changes in concentrations of iron, copper, and zinc change during lactation. For iron, this regulation is achieved by transferrin receptor, DMT1, and ferroportin, whereas mammary gland copper metabolism is regulated by Ctr1, ATP7A, and ATP7B. Zinc homeostasis is complex, involving both zinc importers (Zip3) and zinc exporters (ZnT-1, ZnT-2, and ZnT-4). Both transcriptional and post-translational regulation can affect protein abundance and cellular localization of these transporters, finely orchestrating uptake, intracellular trafficking, and secretion of iron, copper, and zinc. The control of mammary gland uptake and milk secretion of iron, copper, and zinc protects both the mammary gland and the breast-fed infant against deficiency and excess of these nutrients.",
keywords = "Copper, Copper transporters, Interactions, Iron, Iron transporters, Vitamin A, Zinc, Zinc transporters",
author = "Bo L{\"o}nnerdal",
year = "2007",
doi = "10.1146/annurev.nutr.27.061406.093809",
language = "English (US)",
volume = "27",
pages = "165--177",
journal = "Annual Review of Nutrition",
issn = "0199-9885",
publisher = "Annual Reviews Inc.",

}

TY - JOUR

T1 - Trace element transport in the mammary gland

AU - Lönnerdal, Bo

PY - 2007

Y1 - 2007

N2 - The mammary gland has a remarkable capacity to adapt to maternal deficiency or excess of iron, copper, and zinc and to homeostatically control milk concentrations of these essential nutrients. Similarly, it can regulate changes in concentrations of iron, copper, and zinc change during lactation. For iron, this regulation is achieved by transferrin receptor, DMT1, and ferroportin, whereas mammary gland copper metabolism is regulated by Ctr1, ATP7A, and ATP7B. Zinc homeostasis is complex, involving both zinc importers (Zip3) and zinc exporters (ZnT-1, ZnT-2, and ZnT-4). Both transcriptional and post-translational regulation can affect protein abundance and cellular localization of these transporters, finely orchestrating uptake, intracellular trafficking, and secretion of iron, copper, and zinc. The control of mammary gland uptake and milk secretion of iron, copper, and zinc protects both the mammary gland and the breast-fed infant against deficiency and excess of these nutrients.

AB - The mammary gland has a remarkable capacity to adapt to maternal deficiency or excess of iron, copper, and zinc and to homeostatically control milk concentrations of these essential nutrients. Similarly, it can regulate changes in concentrations of iron, copper, and zinc change during lactation. For iron, this regulation is achieved by transferrin receptor, DMT1, and ferroportin, whereas mammary gland copper metabolism is regulated by Ctr1, ATP7A, and ATP7B. Zinc homeostasis is complex, involving both zinc importers (Zip3) and zinc exporters (ZnT-1, ZnT-2, and ZnT-4). Both transcriptional and post-translational regulation can affect protein abundance and cellular localization of these transporters, finely orchestrating uptake, intracellular trafficking, and secretion of iron, copper, and zinc. The control of mammary gland uptake and milk secretion of iron, copper, and zinc protects both the mammary gland and the breast-fed infant against deficiency and excess of these nutrients.

KW - Copper

KW - Copper transporters

KW - Interactions

KW - Iron

KW - Iron transporters

KW - Vitamin A

KW - Zinc

KW - Zinc transporters

UR - http://www.scopus.com/inward/record.url?scp=38449113192&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38449113192&partnerID=8YFLogxK

U2 - 10.1146/annurev.nutr.27.061406.093809

DO - 10.1146/annurev.nutr.27.061406.093809

M3 - Article

C2 - 17506666

AN - SCOPUS:38449113192

VL - 27

SP - 165

EP - 177

JO - Annual Review of Nutrition

JF - Annual Review of Nutrition

SN - 0199-9885

ER -