Toxoplasma and Plasmodium protein kinases: Roles in invasion and host cell remodelling

Daniel C. Lim, Brian M. Cooke, Christian Doerig, Jeroen Saeij

Research output: Contribution to journalReview article

40 Scopus citations

Abstract

Some apicomplexan parasites have evolved distinct protein kinase families to modulate host cell structure and function. Toxoplasma gondii rhoptry protein kinases and pseudokinases are involved in virulence and modulation of host cell signalling. The proteome of Plasmodium falciparum contains a family of putative kinases called FIKKs, some of which are exported to the host red blood cell and might play a role in erythrocyte remodelling. In this review we will discuss kinases known to be critical for host cell invasion, intracellular growth and egress, focusing on (i) calcium-dependent protein kinases and (ii) the secreted kinases that are unique to Toxoplasma (rhoptry protein kinases and pseudokinases) and Plasmodium (FIKKs).

Original languageEnglish (US)
Pages (from-to)21-32
Number of pages12
JournalInternational Journal for Parasitology
Volume42
Issue number1
DOIs
StatePublished - Jan 2012
Externally publishedYes

Keywords

  • Calcium-dependent protein kinase
  • Malaria
  • Plasmodium
  • Protein kinase
  • Red blood cell
  • Rhoptry
  • Toxoplasma

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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