Toxins of Clostridium difficile

J. Glenn Songer, Ashley E. Harmon, Michael K Keel

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The virulence of Clostridium difficile is mediated by two members of the large clostridial cytotoxin family, toxin A (TcdA) and toxin B (TcdB). The genes, tcdA and tcdB, respectively, are located on a large pathogenicity locus (PALoc) in the bacterial chromosome. Toxin synthesis is regulated by an accessory gene regulator quorum-signaling system, mediated via a small thiolactone that can be detected in stools of patients with C. difficile infection (CDI). TcdA and TcdB consist of single, large polypeptide chains with folds stabilized by disulfide bonds. The toxin amino-termini are catalytic and are highly conserved, both function in the target cell cytoplasm by similar mechanisms. Certain strains of C. difficile have recently been associated with widespread epidemics and significantly increased morbidity and mortality attributed to hypervirulence. The most important step in toxin:cell interaction is receptor-mediated uptake of toxins.

Original languageEnglish (US)
Title of host publicationClostridial Diseases in Animals
Publisherwiley
Pages61-70
Number of pages10
ISBN (Electronic)9781118728291
ISBN (Print)9781118728406
DOIs
StatePublished - Apr 8 2016

Keywords

  • Bacterial chromosome
  • Clostridium difficile hypervirulence
  • Clostridium difficile infection
  • Pathogenicity locus
  • Toxin secretion mechanism

ASJC Scopus subject areas

  • veterinary(all)

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  • Cite this

    Songer, J. G., Harmon, A. E., & Keel, M. K. (2016). Toxins of Clostridium difficile. In Clostridial Diseases in Animals (pp. 61-70). wiley. https://doi.org/10.1002/9781118728291.ch6