Toxicology of vanadium compounds in diabetic rats: The action of chelating agents on vanadium accumulation

Jose L. Domingo, Mercedes Gomez, Domenec J. Sanchez, Juan M. Llobet, Carl L Keen

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

The possible use of vanadium compounds in the treatment of diabetic patients is now being evaluated. However, previously to establish the optimal maximum dose for diabetes therapy, it should be taken into account that vanadium is a highly toxic element to man and animals. The toxic effects of vanadium are here reviewed. The tissue vanadium accumulation, which would mean an additional risk of toxicity following prolonged vanadium administration is also discussed. Recently, it has been shown that coadministration of vanadate and TIRON, an effective chelator in the treatment of vanadium intoxication, reduced the tissue accumulation of this element, decreasing the possibility of toxic side effects derived from chronic vanadium administration without diminishing the hypoglycemic effect of vanadium. However, previously to assess the effectiveness of this treatment in diabetic patients, a critical reevaluation of the antidiabetic action of vanadium and its potential toxicity is clearly needed.

Original languageEnglish (US)
Pages (from-to)233-240
Number of pages8
JournalMolecular and Cellular Biochemistry
Volume153
Issue number1-2
DOIs
StatePublished - Dec 1995

Fingerprint

Vanadium Compounds
Vanadium
Chelating Agents
Toxicology
Rats
Poisons
Hypoglycemic Agents
Toxicity
Tissue
Vanadates
Medical problems
Animals
Therapeutics

Keywords

  • streptozotocin-induced diabetes
  • toxic effects
  • vanadate
  • vanadium in tissues
  • vanadyl

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Cell Biology

Cite this

Toxicology of vanadium compounds in diabetic rats : The action of chelating agents on vanadium accumulation. / Domingo, Jose L.; Gomez, Mercedes; Sanchez, Domenec J.; Llobet, Juan M.; Keen, Carl L.

In: Molecular and Cellular Biochemistry, Vol. 153, No. 1-2, 12.1995, p. 233-240.

Research output: Contribution to journalArticle

Domingo, Jose L. ; Gomez, Mercedes ; Sanchez, Domenec J. ; Llobet, Juan M. ; Keen, Carl L. / Toxicology of vanadium compounds in diabetic rats : The action of chelating agents on vanadium accumulation. In: Molecular and Cellular Biochemistry. 1995 ; Vol. 153, No. 1-2. pp. 233-240.
@article{7bc3ddfc856445cb82f6ac89d72e555d,
title = "Toxicology of vanadium compounds in diabetic rats: The action of chelating agents on vanadium accumulation",
abstract = "The possible use of vanadium compounds in the treatment of diabetic patients is now being evaluated. However, previously to establish the optimal maximum dose for diabetes therapy, it should be taken into account that vanadium is a highly toxic element to man and animals. The toxic effects of vanadium are here reviewed. The tissue vanadium accumulation, which would mean an additional risk of toxicity following prolonged vanadium administration is also discussed. Recently, it has been shown that coadministration of vanadate and TIRON, an effective chelator in the treatment of vanadium intoxication, reduced the tissue accumulation of this element, decreasing the possibility of toxic side effects derived from chronic vanadium administration without diminishing the hypoglycemic effect of vanadium. However, previously to assess the effectiveness of this treatment in diabetic patients, a critical reevaluation of the antidiabetic action of vanadium and its potential toxicity is clearly needed.",
keywords = "streptozotocin-induced diabetes, toxic effects, vanadate, vanadium in tissues, vanadyl",
author = "Domingo, {Jose L.} and Mercedes Gomez and Sanchez, {Domenec J.} and Llobet, {Juan M.} and Keen, {Carl L}",
year = "1995",
month = "12",
doi = "10.1007/BF01075942",
language = "English (US)",
volume = "153",
pages = "233--240",
journal = "Molecular and Cellular Biochemistry",
issn = "0300-8177",
publisher = "Springer Netherlands",
number = "1-2",

}

TY - JOUR

T1 - Toxicology of vanadium compounds in diabetic rats

T2 - The action of chelating agents on vanadium accumulation

AU - Domingo, Jose L.

AU - Gomez, Mercedes

AU - Sanchez, Domenec J.

AU - Llobet, Juan M.

AU - Keen, Carl L

PY - 1995/12

Y1 - 1995/12

N2 - The possible use of vanadium compounds in the treatment of diabetic patients is now being evaluated. However, previously to establish the optimal maximum dose for diabetes therapy, it should be taken into account that vanadium is a highly toxic element to man and animals. The toxic effects of vanadium are here reviewed. The tissue vanadium accumulation, which would mean an additional risk of toxicity following prolonged vanadium administration is also discussed. Recently, it has been shown that coadministration of vanadate and TIRON, an effective chelator in the treatment of vanadium intoxication, reduced the tissue accumulation of this element, decreasing the possibility of toxic side effects derived from chronic vanadium administration without diminishing the hypoglycemic effect of vanadium. However, previously to assess the effectiveness of this treatment in diabetic patients, a critical reevaluation of the antidiabetic action of vanadium and its potential toxicity is clearly needed.

AB - The possible use of vanadium compounds in the treatment of diabetic patients is now being evaluated. However, previously to establish the optimal maximum dose for diabetes therapy, it should be taken into account that vanadium is a highly toxic element to man and animals. The toxic effects of vanadium are here reviewed. The tissue vanadium accumulation, which would mean an additional risk of toxicity following prolonged vanadium administration is also discussed. Recently, it has been shown that coadministration of vanadate and TIRON, an effective chelator in the treatment of vanadium intoxication, reduced the tissue accumulation of this element, decreasing the possibility of toxic side effects derived from chronic vanadium administration without diminishing the hypoglycemic effect of vanadium. However, previously to assess the effectiveness of this treatment in diabetic patients, a critical reevaluation of the antidiabetic action of vanadium and its potential toxicity is clearly needed.

KW - streptozotocin-induced diabetes

KW - toxic effects

KW - vanadate

KW - vanadium in tissues

KW - vanadyl

UR - http://www.scopus.com/inward/record.url?scp=0029559529&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029559529&partnerID=8YFLogxK

U2 - 10.1007/BF01075942

DO - 10.1007/BF01075942

M3 - Article

C2 - 8927043

AN - SCOPUS:0029559529

VL - 153

SP - 233

EP - 240

JO - Molecular and Cellular Biochemistry

JF - Molecular and Cellular Biochemistry

SN - 0300-8177

IS - 1-2

ER -