Toxicological function of adipose tissue: Focus on persistent organic pollutants

Michele La Merrill, Claude Emond, Min Ji Kim, Jean Philippe Antignac, Bruno Le Bizec, Karine Clément, Linda S. Birnbaum, Robert Barouki

Research output: Contribution to journalReview article

148 Scopus citations

Abstract

Background: A dipose tissue (AT) is involved in several physiological functions, including metabolic regulation, energy storage, and endocrine functions. Objectives: In this review we examined the evidence that an additional function of AT is to modulate persistent organic pollutant (POP) toxicity through several mechanisms. Methods: We reviewed the literature on the interaction of AT with POPs to provide a comprehensive model for this additional function of AT. discussion: As a storage compartment for lipophilic POPs, AT plays a critical role in the toxico-kinetics of a variety of drugs and pollutants, in particular, POPs. By sequestering POPs, AT can protect other organs and tissues from POPs overload. However, this protective function could prove to be a threat in the long run. Te accumulation of lipophilic POPs will increase total body burden. These accumulated POPs are slowly released into the bloodstream, and more so during weight loss. Thus, AT constitutes a continual source of internal exposure to POPs. In addition to its buffering function, AT is also a target of POPs and may mediate part of their metabolic effects. This is particularly relevant because many POPs induce obesogenic effects that may lead to quantitative and qualitative alterations of AT. Some POPs also induce a proinflammatory state in AT, which may lead to detrimental metabolic effects. Conclusion: AT appears to play diverse functions both as a modulator and as a target of POPs toxicity.

Original languageEnglish (US)
Pages (from-to)162-169
Number of pages8
JournalEnvironmental Health Perspectives
Volume121
Issue number2
DOIs
StatePublished - Feb 1 2013
Externally publishedYes

Keywords

  • Adipose tissue
  • Aryl hydrocarbon receptor
  • Development
  • Diabetes
  • Dioxin
  • Inflammation
  • Obesity
  • Obesogens
  • Polychlorinated biphenyls
  • Toxicity
  • Toxicokinetics

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Fingerprint Dive into the research topics of 'Toxicological function of adipose tissue: Focus on persistent organic pollutants'. Together they form a unique fingerprint.

  • Cite this

    La Merrill, M., Emond, C., Kim, M. J., Antignac, J. P., Le Bizec, B., Clément, K., Birnbaum, L. S., & Barouki, R. (2013). Toxicological function of adipose tissue: Focus on persistent organic pollutants. Environmental Health Perspectives, 121(2), 162-169. https://doi.org/10.1289/ehp.1205485