Toxicity and pharmacology of extracts from dorid nudibranches.

F. A. Fuhrman, G. J. Fuhrman, K. DeRiemer

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

1. Aqueous extracts of digestive glands of specimens of the dorid nudibranchs Cadlina flavomaculata, Doriopsilla albopunctata, Anisodoris nobilis, Archidoris montereyenis, and A. odhneri were lethal when injected into shore crabs and when injected intraperitoneally into mice. 2. Aqueous extracts of the degestive glands of Doriopsilla albopunctata and of Anisodoris nobilis were shown by bioassay (guinea pig ileum)and by chemical determination to contain histamine. The amount present was far too small to account for the toxicity of the glands. 3. Extracts of the digestive glands of Anisodoris nobilis were fractionated by column chromatography on Biogel P-2 to yield an active fraction designated "dorid toxin". This produces lethargy and bradycardia in mice. In anesthetized rats it produces sustained (60 min or more) bradycardia and hypotension. On isolated hearts, especially spontaneously beating guinea pig atria, it has negative inotropic and chronotropic effects. 4. Dorid toxin has a molecular weight under 8000. It is heat stable and is not destroyed by trypsin, chymotrypsin or Pronase. It is therefore unlikely that it is a polypeptide.

Original languageEnglish (US)
Pages (from-to)289-299
Number of pages11
JournalBiological Bulletin
Volume156
Issue number3
StatePublished - Jun 1979
Externally publishedYes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)
  • Aquatic Science

Fingerprint Dive into the research topics of 'Toxicity and pharmacology of extracts from dorid nudibranches.'. Together they form a unique fingerprint.

  • Cite this

    Fuhrman, F. A., Fuhrman, G. J., & DeRiemer, K. (1979). Toxicity and pharmacology of extracts from dorid nudibranches. Biological Bulletin, 156(3), 289-299.