Abstract
Yearling trout were administered fumagillin dicyclohexylamine (FDCH), an antibiotic that has shown promise for controlling myxozoan parasites in fish. FDCH was fed at 0.25 or 1 g/kg food at 1.5% body weight per day for 60 days, and gill, liver, kidney, spleen, thymus, intestine, and heart were examined histologically. In both treatment groups the hematopoietic tissue of the kidney and spleen was reduced and hematocrit was significantly lower relative to controls. No alteration was found in liver, intestine, heart, thymus, or gill. FDCH was also administered to trout through an indwelling catheter placed in the dorsal aorta. Plasma FDCH was measured using reverse-phase HPLC, and clearance microconstants were estimated. At the highest doses (60 and 30 mg/kg body wt) fumagillin was lethal within about 6 hr, and histological examination revealed extensive toxic alteration in liver and posterior kidney. Plasma clearance at 6 and 3 mg/kg fit a two-compartment model with a rapid α phase (i.e., 20 min) but a prolonged β phase (5.4 days). Although these fish survived for at least 96 hr, renal tubular alteration remained.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 444-453 |
| Number of pages | 10 |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 98 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 1989 |
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ASJC Scopus subject areas
- Toxicology
- Pharmacology
Cite this
Toxicity and pharmacokinetics of the antibiotic fumagillin in yearling rainbow trout (Salmo gairdneri). / Laurén, Darrel J.; Wishkovsky, Arieh; Groff, Joseph M.; Hedrick, Ronald; Hinton, David E.
In: Toxicology and Applied Pharmacology, Vol. 98, No. 3, 01.01.1989, p. 444-453.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Toxicity and pharmacokinetics of the antibiotic fumagillin in yearling rainbow trout (Salmo gairdneri)
AU - Laurén, Darrel J.
AU - Wishkovsky, Arieh
AU - Groff, Joseph M.
AU - Hedrick, Ronald
AU - Hinton, David E.
PY - 1989/1/1
Y1 - 1989/1/1
N2 - Yearling trout were administered fumagillin dicyclohexylamine (FDCH), an antibiotic that has shown promise for controlling myxozoan parasites in fish. FDCH was fed at 0.25 or 1 g/kg food at 1.5% body weight per day for 60 days, and gill, liver, kidney, spleen, thymus, intestine, and heart were examined histologically. In both treatment groups the hematopoietic tissue of the kidney and spleen was reduced and hematocrit was significantly lower relative to controls. No alteration was found in liver, intestine, heart, thymus, or gill. FDCH was also administered to trout through an indwelling catheter placed in the dorsal aorta. Plasma FDCH was measured using reverse-phase HPLC, and clearance microconstants were estimated. At the highest doses (60 and 30 mg/kg body wt) fumagillin was lethal within about 6 hr, and histological examination revealed extensive toxic alteration in liver and posterior kidney. Plasma clearance at 6 and 3 mg/kg fit a two-compartment model with a rapid α phase (i.e., 20 min) but a prolonged β phase (5.4 days). Although these fish survived for at least 96 hr, renal tubular alteration remained.
AB - Yearling trout were administered fumagillin dicyclohexylamine (FDCH), an antibiotic that has shown promise for controlling myxozoan parasites in fish. FDCH was fed at 0.25 or 1 g/kg food at 1.5% body weight per day for 60 days, and gill, liver, kidney, spleen, thymus, intestine, and heart were examined histologically. In both treatment groups the hematopoietic tissue of the kidney and spleen was reduced and hematocrit was significantly lower relative to controls. No alteration was found in liver, intestine, heart, thymus, or gill. FDCH was also administered to trout through an indwelling catheter placed in the dorsal aorta. Plasma FDCH was measured using reverse-phase HPLC, and clearance microconstants were estimated. At the highest doses (60 and 30 mg/kg body wt) fumagillin was lethal within about 6 hr, and histological examination revealed extensive toxic alteration in liver and posterior kidney. Plasma clearance at 6 and 3 mg/kg fit a two-compartment model with a rapid α phase (i.e., 20 min) but a prolonged β phase (5.4 days). Although these fish survived for at least 96 hr, renal tubular alteration remained.
UR - http://www.scopus.com/inward/record.url?scp=0024598408&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024598408&partnerID=8YFLogxK
U2 - 10.1016/0041-008X(89)90173-7
DO - 10.1016/0041-008X(89)90173-7
M3 - Article
C2 - 2718173
AN - SCOPUS:0024598408
VL - 98
SP - 444
EP - 453
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
SN - 0041-008X
IS - 3
ER -