Toxic Neuropathies

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Toxic neuropathies most often present with symmetrical distal sensory loss, but sometimes affect exclusively motor or autonomic function, and very occasionally show features suggesting mononeuritis multiplex. Evidence of central nervous system dysfunction may also be present. The most common etiologic suspects are drugs, especially antineoplastic and antibacterial agents, organic solvents, organophosphorus compounds, and heavy metals. Obtaining a detailed medical and social history is crucial in arriving at the correct diagnosis. Electrophysiological studies are helpful in documenting the presence of neuropathy. In most instances, preventing continued exposure to the neurotoxic agent is sufficient to permit recovery, or at least to prevent further progression of clinical deficits.

Original languageEnglish (US)
Title of host publicationNeuromuscular Disorders of Infancy, Childhood, and Adolescence: A Clinician's Approach
PublisherElsevier Inc.
Pages431-437
Number of pages7
ISBN (Print)9780124171275, 9780124170445
DOIs
StatePublished - Dec 3 2014

Keywords

  • Arsenic
  • Buckthorn
  • Chloroquine
  • Cisplatin
  • Colchicine
  • Hexane
  • Metronidazole
  • Nitrofurantoin
  • Organophosphates
  • Paclitaxel
  • Pyridoxine
  • Thalidomide
  • Thallium
  • Toxic neuropathy
  • Vincristine

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

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  • Cite this

    Pleasure, D. E. (2014). Toxic Neuropathies. In Neuromuscular Disorders of Infancy, Childhood, and Adolescence: A Clinician's Approach (pp. 431-437). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-417044-5.00023-8