Toxic neuropathies most often present with symmetrical distal sensory loss, but sometimes affect exclusively motor or autonomic function, and very occasionally show features suggesting mononeuritis multiplex. Evidence of central nervous system dysfunction may also be present. The most common etiologic suspects are drugs, especially antineoplastic and antibacterial agents, organic solvents, organophosphorus compounds, and heavy metals. Obtaining a detailed medical and social history is crucial in arriving at the correct diagnosis. Electrophysiological studies are helpful in documenting the presence of neuropathy. In most instances, preventing continued exposure to the neurotoxic agent is sufficient to permit recovery, or at least to prevent further progression of clinical deficits.
|Original language||English (US)|
|Title of host publication||Neuromuscular Disorders of Infancy, Childhood, and Adolescence: A Clinician's Approach|
|Number of pages||7|
|ISBN (Print)||9780124171275, 9780124170445|
|State||Published - Dec 3 2014|
- Toxic neuropathy
ASJC Scopus subject areas