Toxic Equine Parkinsonism: An Immunohistochemical Study of 10 Horses With Nigropallidal Encephalomalacia

H. T. Chang, W. K. Rumbeiha, J. S. Patterson, Birgit Puschner, A. P. Knight

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Chronic ingestion of yellow star thistle (Centaurea solstitialis) or Russian knapweed (Acroptilon repens) causes nigropallidal encephalomalacia (NPE) in horses with an abrupt onset of neurologic signs characterized by dystonia of lips and tongue, inability to prehend food, depression, and locomotor deficits. The objectives of this study were to reexamine the pathologic alterations of NPE and to conduct an immunohistochemistry study using antibodies to tyrosine hydroxylase and α-synuclein, to determine whether NPE brains show histopathologic features resembling those in human Parkinson disease. Results confirm that the NPE lesions are located within the substantia nigra pars reticulata, sparing the cell bodies of the dopaminergic neurons in the substantia nigra pars compacta, and in the rostral portion of the globus pallidus, with partial disruption of dopaminergic (tyrosine hydroxylase-positive) fibers passing through the globus pallidus. No abnormal cytoplasmic inclusions like the Lewy bodies of human Parkinson disease were seen in these NPE brains. These findings indicate that equine NPE may serve as a large animal model of environmentally acquired toxic parkinsonism, with clinical phenotype directly attributable to lesions in globus pallidus and substantia nigra pars reticulata rather than to the destruction of dopaminergic neurons.

Original languageEnglish (US)
Pages (from-to)398-402
Number of pages5
JournalVeterinary Pathology
Volume49
Issue number2
DOIs
StatePublished - Mar 2012

Fingerprint

Encephalomalacia
encephalomalacia
Poisons
Parkinsonian Disorders
Horses
Centaurea
horses
Globus Pallidus
tyrosine 3-monooxygenase
Rhaponticum repens
Centaurea solstitialis
Parkinson disease
Dopaminergic Neurons
Tyrosine 3-Monooxygenase
lesions (animal)
Parkinson Disease
Synucleins
neurons
cytoplasmic inclusions
brain

Keywords

  • equine nigropallidal encephalomalacia
  • equine parkinsonism
  • Hallervorden-Spatz
  • synucleinopathy

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Toxic Equine Parkinsonism : An Immunohistochemical Study of 10 Horses With Nigropallidal Encephalomalacia. / Chang, H. T.; Rumbeiha, W. K.; Patterson, J. S.; Puschner, Birgit; Knight, A. P.

In: Veterinary Pathology, Vol. 49, No. 2, 03.2012, p. 398-402.

Research output: Contribution to journalArticle

Chang, H. T. ; Rumbeiha, W. K. ; Patterson, J. S. ; Puschner, Birgit ; Knight, A. P. / Toxic Equine Parkinsonism : An Immunohistochemical Study of 10 Horses With Nigropallidal Encephalomalacia. In: Veterinary Pathology. 2012 ; Vol. 49, No. 2. pp. 398-402.
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