Towards development of an intravascular diagnostic catheter based on fluorescence lifetime spectroscopy: Study of an optimized blood flushing system

Narugopal Ghata, Ralph C. Aldredge, Julien Bec, Laura Marcu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Fluorescence lifetime spectroscopy has demonstrated potential for characterization and diagnosis of arterial vessels pathologies. However, the intravascular application of such technique is hampered by the presence of blood hemoglobin that affects both the delivery of the excitation light to and the collection of the fluorescence light from the vessel wall. We report here a computational fluid dynamics model that allows for the optimization of blood flushing parameters in a manner that minimizes the amount of saline needed to clear the optical field of view. A 3D turbulence (k - ∈) model was employed to simulate the flow inside and around a side-viewing fiber-optic catheter. The influence of various infusion rates, blood flow rates and vessel diameters on the flow around the catheter tip and its effects on the wall shear stress (WSS) are studied. Current results suggest that low flushing rates in smaller-diameter vessels (e.g., stenotic vessels) can produce better flushing efficiency by removing the blood cells in the path of the fluorescence light and reducing wall shear stress. The comparison of the results for blood vessels with equal diameter but different flow rates suggests that the effect of systolic and diastolic conditions on the maximum wall shear stress is not substantial. The results from this study can be utilized in determining the optimal flushing rate depending on the diameter of the vessels, blood flow rate, and the maximum wall shear stress that vessel wall can sustain, which can be estimated from the feedback of the fluorescent light from the wall.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7883
DOIs
StatePublished - 2011
EventPhotonic Therapeutics and Diagnostics VII - San Francisco, CA, United States
Duration: Jan 22 2011Jan 24 2011

Other

OtherPhotonic Therapeutics and Diagnostics VII
CountryUnited States
CitySan Francisco, CA
Period1/22/111/24/11

Fingerprint

flushing
Catheters
Fluorescence Spectrometry
blood
vessels
Shear stress
Blood
Fluorescence
Spectroscopy
Light
life (durability)
fluorescence
Flow rate
Blood vessels
shear stress
spectroscopy
Blood Vessels
flow velocity
blood flow
Hemoglobin

Keywords

  • Catheter
  • Mixing model
  • Turbulence model

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Ghata, N., Aldredge, R. C., Bec, J., & Marcu, L. (2011). Towards development of an intravascular diagnostic catheter based on fluorescence lifetime spectroscopy: Study of an optimized blood flushing system. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7883). [78833E] https://doi.org/10.1117/12.874957

Towards development of an intravascular diagnostic catheter based on fluorescence lifetime spectroscopy : Study of an optimized blood flushing system. / Ghata, Narugopal; Aldredge, Ralph C.; Bec, Julien; Marcu, Laura.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7883 2011. 78833E.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ghata, N, Aldredge, RC, Bec, J & Marcu, L 2011, Towards development of an intravascular diagnostic catheter based on fluorescence lifetime spectroscopy: Study of an optimized blood flushing system. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 7883, 78833E, Photonic Therapeutics and Diagnostics VII, San Francisco, CA, United States, 1/22/11. https://doi.org/10.1117/12.874957
Ghata N, Aldredge RC, Bec J, Marcu L. Towards development of an intravascular diagnostic catheter based on fluorescence lifetime spectroscopy: Study of an optimized blood flushing system. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7883. 2011. 78833E https://doi.org/10.1117/12.874957
Ghata, Narugopal ; Aldredge, Ralph C. ; Bec, Julien ; Marcu, Laura. / Towards development of an intravascular diagnostic catheter based on fluorescence lifetime spectroscopy : Study of an optimized blood flushing system. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7883 2011.
@inproceedings{3873774ab0104aba882c7dc30ad3855c,
title = "Towards development of an intravascular diagnostic catheter based on fluorescence lifetime spectroscopy: Study of an optimized blood flushing system",
abstract = "Fluorescence lifetime spectroscopy has demonstrated potential for characterization and diagnosis of arterial vessels pathologies. However, the intravascular application of such technique is hampered by the presence of blood hemoglobin that affects both the delivery of the excitation light to and the collection of the fluorescence light from the vessel wall. We report here a computational fluid dynamics model that allows for the optimization of blood flushing parameters in a manner that minimizes the amount of saline needed to clear the optical field of view. A 3D turbulence (k - ∈) model was employed to simulate the flow inside and around a side-viewing fiber-optic catheter. The influence of various infusion rates, blood flow rates and vessel diameters on the flow around the catheter tip and its effects on the wall shear stress (WSS) are studied. Current results suggest that low flushing rates in smaller-diameter vessels (e.g., stenotic vessels) can produce better flushing efficiency by removing the blood cells in the path of the fluorescence light and reducing wall shear stress. The comparison of the results for blood vessels with equal diameter but different flow rates suggests that the effect of systolic and diastolic conditions on the maximum wall shear stress is not substantial. The results from this study can be utilized in determining the optimal flushing rate depending on the diameter of the vessels, blood flow rate, and the maximum wall shear stress that vessel wall can sustain, which can be estimated from the feedback of the fluorescent light from the wall.",
keywords = "Catheter, Mixing model, Turbulence model",
author = "Narugopal Ghata and Aldredge, {Ralph C.} and Julien Bec and Laura Marcu",
year = "2011",
doi = "10.1117/12.874957",
language = "English (US)",
isbn = "9780819484208",
volume = "7883",
booktitle = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

}

TY - GEN

T1 - Towards development of an intravascular diagnostic catheter based on fluorescence lifetime spectroscopy

T2 - Study of an optimized blood flushing system

AU - Ghata, Narugopal

AU - Aldredge, Ralph C.

AU - Bec, Julien

AU - Marcu, Laura

PY - 2011

Y1 - 2011

N2 - Fluorescence lifetime spectroscopy has demonstrated potential for characterization and diagnosis of arterial vessels pathologies. However, the intravascular application of such technique is hampered by the presence of blood hemoglobin that affects both the delivery of the excitation light to and the collection of the fluorescence light from the vessel wall. We report here a computational fluid dynamics model that allows for the optimization of blood flushing parameters in a manner that minimizes the amount of saline needed to clear the optical field of view. A 3D turbulence (k - ∈) model was employed to simulate the flow inside and around a side-viewing fiber-optic catheter. The influence of various infusion rates, blood flow rates and vessel diameters on the flow around the catheter tip and its effects on the wall shear stress (WSS) are studied. Current results suggest that low flushing rates in smaller-diameter vessels (e.g., stenotic vessels) can produce better flushing efficiency by removing the blood cells in the path of the fluorescence light and reducing wall shear stress. The comparison of the results for blood vessels with equal diameter but different flow rates suggests that the effect of systolic and diastolic conditions on the maximum wall shear stress is not substantial. The results from this study can be utilized in determining the optimal flushing rate depending on the diameter of the vessels, blood flow rate, and the maximum wall shear stress that vessel wall can sustain, which can be estimated from the feedback of the fluorescent light from the wall.

AB - Fluorescence lifetime spectroscopy has demonstrated potential for characterization and diagnosis of arterial vessels pathologies. However, the intravascular application of such technique is hampered by the presence of blood hemoglobin that affects both the delivery of the excitation light to and the collection of the fluorescence light from the vessel wall. We report here a computational fluid dynamics model that allows for the optimization of blood flushing parameters in a manner that minimizes the amount of saline needed to clear the optical field of view. A 3D turbulence (k - ∈) model was employed to simulate the flow inside and around a side-viewing fiber-optic catheter. The influence of various infusion rates, blood flow rates and vessel diameters on the flow around the catheter tip and its effects on the wall shear stress (WSS) are studied. Current results suggest that low flushing rates in smaller-diameter vessels (e.g., stenotic vessels) can produce better flushing efficiency by removing the blood cells in the path of the fluorescence light and reducing wall shear stress. The comparison of the results for blood vessels with equal diameter but different flow rates suggests that the effect of systolic and diastolic conditions on the maximum wall shear stress is not substantial. The results from this study can be utilized in determining the optimal flushing rate depending on the diameter of the vessels, blood flow rate, and the maximum wall shear stress that vessel wall can sustain, which can be estimated from the feedback of the fluorescent light from the wall.

KW - Catheter

KW - Mixing model

KW - Turbulence model

UR - http://www.scopus.com/inward/record.url?scp=79953740105&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79953740105&partnerID=8YFLogxK

U2 - 10.1117/12.874957

DO - 10.1117/12.874957

M3 - Conference contribution

AN - SCOPUS:79953740105

SN - 9780819484208

VL - 7883

BT - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

ER -