Toward a consensus on the operation of receptor-induced calcium entry signals.

Donald L. Gill, Randen L. Patterson

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Receptor-induced Ca2+ signals involve both Ca2+ release from intracellular stores and extracellular Ca2+ entry across the plasma membrane. The channels mediating Ca2+ entry and the mechanisms controlling their function remain largely a mystery. Here we critically assess current views on the Ca2+ entry process and consider certain modifications to the widely held hypothesis that Ca2+ store emptying is the fundamental trigger for receptor-induced Ca2+ entry channels. Under physiological conditions, receptor-induced store depletion may be quite limited. A number of distinct channel activities appear to mediate receptor-induced Ca2+ entry, and their activation is observed to occur through quite diverse coupling processes.

Original languageEnglish (US)
JournalScience's STKE : signal transduction knowledge environment
Volume2004
Issue number243
StatePublished - 2004
Externally publishedYes

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