Abstract
Receptor-induced Ca2+ signals involve both Ca2+ release from intracellular stores and extracellular Ca2+ entry across the plasma membrane. The channels mediating Ca2+ entry and the mechanisms controlling their function remain largely a mystery. Here we critically assess current views on the Ca2+ entry process and consider certain modifications to the widely held hypothesis that Ca2+ store emptying is the fundamental trigger for receptor-induced Ca2+ entry channels. Under physiological conditions, receptor-induced store depletion may be quite limited. A number of distinct channel activities appear to mediate receptor-induced Ca2+ entry, and their activation is observed to occur through quite diverse coupling processes.
| Original language | English (US) |
|---|---|
| Journal | Science's STKE : signal transduction knowledge environment |
| Volume | 2004 |
| Issue number | 243 |
| State | Published - 2004 |
| Externally published | Yes |
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Toward a consensus on the operation of receptor-induced calcium entry signals. / Gill, Donald L.; Patterson, Randen L.
In: Science's STKE : signal transduction knowledge environment, Vol. 2004, No. 243, 2004.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Toward a consensus on the operation of receptor-induced calcium entry signals.
AU - Gill, Donald L.
AU - Patterson, Randen L.
PY - 2004
Y1 - 2004
N2 - Receptor-induced Ca2+ signals involve both Ca2+ release from intracellular stores and extracellular Ca2+ entry across the plasma membrane. The channels mediating Ca2+ entry and the mechanisms controlling their function remain largely a mystery. Here we critically assess current views on the Ca2+ entry process and consider certain modifications to the widely held hypothesis that Ca2+ store emptying is the fundamental trigger for receptor-induced Ca2+ entry channels. Under physiological conditions, receptor-induced store depletion may be quite limited. A number of distinct channel activities appear to mediate receptor-induced Ca2+ entry, and their activation is observed to occur through quite diverse coupling processes.
AB - Receptor-induced Ca2+ signals involve both Ca2+ release from intracellular stores and extracellular Ca2+ entry across the plasma membrane. The channels mediating Ca2+ entry and the mechanisms controlling their function remain largely a mystery. Here we critically assess current views on the Ca2+ entry process and consider certain modifications to the widely held hypothesis that Ca2+ store emptying is the fundamental trigger for receptor-induced Ca2+ entry channels. Under physiological conditions, receptor-induced store depletion may be quite limited. A number of distinct channel activities appear to mediate receptor-induced Ca2+ entry, and their activation is observed to occur through quite diverse coupling processes.
UR - http://www.scopus.com/inward/record.url?scp=19244365325&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=19244365325&partnerID=8YFLogxK
M3 - Article
C2 - 15280581
AN - SCOPUS:19244365325
VL - 2004
JO - Science Signaling
JF - Science Signaling
SN - 1937-9145
IS - 243
ER -