Abstract
Gene expression microarrays are a high-throughput, cost-effective method for measuring the expression of all genes in a sample. By comparing the expression patterns of healthy controls to diseased subjects, the genetic regulatory pathways underlying and affected by the disease can be elucidated. Furthermore, dysregulated genes are possible candidates for pharmaceutical therapy. Here, we consider the possibility of applying this approach to Tourette syndrome. We also review current theories of Tourette syndrome etiology and pharmacology.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 302-306 |
| Number of pages | 5 |
| Journal | Neurotherapeutics |
| Volume | 7 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jul 2010 |
Keywords
- Gene expression
- Microarrays
- Pharmacology
- Tourette syndrome
ASJC Scopus subject areas
- Pharmacology (medical)
- Clinical Neurology
- Pharmacology
- Medicine(all)
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Cite this
Liao, I. H., & Sharp, F. R. (2010). Tourette syndrome: Gene expression as a tool to discover drug targets. Neurotherapeutics, 7(3), 302-306. https://doi.org/10.1016/j.nurt.2010.05.007