Tourette syndrome: Gene expression as a tool to discover drug targets

Isaac H. Liao, Frank R Sharp

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Gene expression microarrays are a high-throughput, cost-effective method for measuring the expression of all genes in a sample. By comparing the expression patterns of healthy controls to diseased subjects, the genetic regulatory pathways underlying and affected by the disease can be elucidated. Furthermore, dysregulated genes are possible candidates for pharmaceutical therapy. Here, we consider the possibility of applying this approach to Tourette syndrome. We also review current theories of Tourette syndrome etiology and pharmacology.

Original languageEnglish (US)
Pages (from-to)302-306
Number of pages5
JournalNeurotherapeutics
Volume7
Issue number3
DOIs
StatePublished - Jul 2010

Keywords

  • Gene expression
  • Microarrays
  • Pharmacology
  • Tourette syndrome

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Clinical Neurology
  • Pharmacology
  • Medicine(all)

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