Abstract
A convenient approach to the functionalization of peptides with the macrocyclic 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid (DOTA) moiety has been developed. Protected components (using tert-butyl or tert-butyloxycarbonyl groups) of both the peptide and the chelate were assembled on the same solid resin support. Deprotection and cleavage of the resin-bound DOTA-peptides were performed in one step using a trifluoroacetic acid cleavage mixture to yield free DOTA-peptide amides.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 316-320 |
| Number of pages | 5 |
| Journal | Bioconjugate Chemistry |
| Volume | 10 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 1999 |
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ASJC Scopus subject areas
- Chemistry(all)
- Organic Chemistry
- Clinical Biochemistry
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
Cite this
Total solid-phase synthesis of 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid-functionalized peptides for radioimmunotherapy. / Peterson, James J.; Pak, Roger H.; Meares, Claude F.
In: Bioconjugate Chemistry, Vol. 10, No. 2, 03.1999, p. 316-320.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Total solid-phase synthesis of 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid-functionalized peptides for radioimmunotherapy
AU - Peterson, James J.
AU - Pak, Roger H.
AU - Meares, Claude F.
PY - 1999/3
Y1 - 1999/3
N2 - A convenient approach to the functionalization of peptides with the macrocyclic 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid (DOTA) moiety has been developed. Protected components (using tert-butyl or tert-butyloxycarbonyl groups) of both the peptide and the chelate were assembled on the same solid resin support. Deprotection and cleavage of the resin-bound DOTA-peptides were performed in one step using a trifluoroacetic acid cleavage mixture to yield free DOTA-peptide amides.
AB - A convenient approach to the functionalization of peptides with the macrocyclic 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid (DOTA) moiety has been developed. Protected components (using tert-butyl or tert-butyloxycarbonyl groups) of both the peptide and the chelate were assembled on the same solid resin support. Deprotection and cleavage of the resin-bound DOTA-peptides were performed in one step using a trifluoroacetic acid cleavage mixture to yield free DOTA-peptide amides.
UR - http://www.scopus.com/inward/record.url?scp=0033104341&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033104341&partnerID=8YFLogxK
U2 - 10.1021/bc980118t
DO - 10.1021/bc980118t
M3 - Article
C2 - 10077483
AN - SCOPUS:0033104341
VL - 10
SP - 316
EP - 320
JO - Bioconjugate Chemistry
JF - Bioconjugate Chemistry
SN - 1043-1802
IS - 2
ER -