Total laryngectomy negatively impacts sinonasal and olfactory-specific quality of life

Joy Chen; Roberto N. Solis; Mehrnaz Mehrzad; Amarbir Gill; Beverly Garber; Angela M. Beliveau; Arnaud F. Bewley; Toby O. Steele; Andrew C. Birkeland; Marianne Abouyared

doi:10.1016/j.amjoto.2022.103471

Total laryngectomy negatively impacts sinonasal and olfactory-specific quality of life

Joy Chen, Roberto N. Solis, Mehrnaz Mehrzad, Amarbir Gill, Beverly Garber, Angela M. Beliveau, Arnaud F. Bewley, Toby O. Steele, Andrew C. Birkeland, Marianne Abouyared

Otolaryngology

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: The purpose of this study is to characterize deficits in olfactory-specific and sinonasal-specific QoL after total laryngectomy (TL) with validated patient reported outcome measures. Methods: Thirty patients who had a TL were prospectively enrolled. Patient demographics, as well as scores from the Questionnaire of Olfactory Disorders Negative Statements (QOD-NS) and the Sino-nasal Outcome Test-22 (SNOT-22) were collected. Univariate analysis was performed to assess associations between patient characteristics and QoL scores. Results: The average QOD-NS score was 37.9 ± 11.4 (<38.5 is considered abnormal) and average SNOT-22 score was 32.0 ± 3.8 (>20 indicates a moderate/severe impact on QoL). The abnormal QOD-NS group had a greater percentage of former smokers compared to the normal group (77.8% vs. 58.1%; P = 0.56) and more median days from surgery compared to the normal group (904 vs. 477 days; P = 0.24). Conclusions: Olfactory dysfunction associated with TL results in blunting of olfactory-specific QoL.

Original language	English (US)
Article number	103471
Journal	American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume	43
Issue number	4
DOIs	https://doi.org/10.1016/j.amjoto.2022.103471
State	Published - Jul 1 2022

Keywords

Head and neck cancer
QOD-NS
Quality of life
SNOT-22
Total laryngectomy

ASJC Scopus subject areas

Otorhinolaryngology

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10.1016/j.amjoto.2022.103471

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Chen, J., Solis, R. N., Mehrzad, M., Gill, A., Garber, B., Beliveau, A. M., Bewley, A. F., Steele, T. O., Birkeland, A. C., & Abouyared, M. (2022). Total laryngectomy negatively impacts sinonasal and olfactory-specific quality of life. American Journal of Otolaryngology - Head and Neck Medicine and Surgery, 43(4), [103471]. https://doi.org/10.1016/j.amjoto.2022.103471

Total laryngectomy negatively impacts sinonasal and olfactory-specific quality of life. / Chen, Joy; Solis, Roberto N.; Mehrzad, Mehrnaz; Gill, Amarbir; Garber, Beverly; Beliveau, Angela M.; Bewley, Arnaud F.; Steele, Toby O.; Birkeland, Andrew C.; Abouyared, Marianne.

In: American Journal of Otolaryngology - Head and Neck Medicine and Surgery, Vol. 43, No. 4, 103471, 01.07.2022.

Research output: Contribution to journal › Article › peer-review

Chen, Joy ; Solis, Roberto N. ; Mehrzad, Mehrnaz ; Gill, Amarbir ; Garber, Beverly ; Beliveau, Angela M. ; Bewley, Arnaud F. ; Steele, Toby O. ; Birkeland, Andrew C. ; Abouyared, Marianne. / Total laryngectomy negatively impacts sinonasal and olfactory-specific quality of life. In: American Journal of Otolaryngology - Head and Neck Medicine and Surgery. 2022 ; Vol. 43, No. 4.

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abstract = "Purpose: The purpose of this study is to characterize deficits in olfactory-specific and sinonasal-specific QoL after total laryngectomy (TL) with validated patient reported outcome measures. Methods: Thirty patients who had a TL were prospectively enrolled. Patient demographics, as well as scores from the Questionnaire of Olfactory Disorders Negative Statements (QOD-NS) and the Sino-nasal Outcome Test-22 (SNOT-22) were collected. Univariate analysis was performed to assess associations between patient characteristics and QoL scores. Results: The average QOD-NS score was 37.9 ± 11.4 (<38.5 is considered abnormal) and average SNOT-22 score was 32.0 ± 3.8 (>20 indicates a moderate/severe impact on QoL). The abnormal QOD-NS group had a greater percentage of former smokers compared to the normal group (77.8% vs. 58.1%; P = 0.56) and more median days from surgery compared to the normal group (904 vs. 477 days; P = 0.24). Conclusions: Olfactory dysfunction associated with TL results in blunting of olfactory-specific QoL.",

keywords = "Head and neck cancer, QOD-NS, Quality of life, SNOT-22, Total laryngectomy",

author = "Joy Chen and Solis, {Roberto N.} and Mehrnaz Mehrzad and Amarbir Gill and Beverly Garber and Beliveau, {Angela M.} and Bewley, {Arnaud F.} and Steele, {Toby O.} and Birkeland, {Andrew C.} and Marianne Abouyared",

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AU - Gill, Amarbir

AU - Garber, Beverly

AU - Beliveau, Angela M.

AU - Bewley, Arnaud F.

AU - Steele, Toby O.

AU - Birkeland, Andrew C.

AU - Abouyared, Marianne

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N2 - Purpose: The purpose of this study is to characterize deficits in olfactory-specific and sinonasal-specific QoL after total laryngectomy (TL) with validated patient reported outcome measures. Methods: Thirty patients who had a TL were prospectively enrolled. Patient demographics, as well as scores from the Questionnaire of Olfactory Disorders Negative Statements (QOD-NS) and the Sino-nasal Outcome Test-22 (SNOT-22) were collected. Univariate analysis was performed to assess associations between patient characteristics and QoL scores. Results: The average QOD-NS score was 37.9 ± 11.4 (<38.5 is considered abnormal) and average SNOT-22 score was 32.0 ± 3.8 (>20 indicates a moderate/severe impact on QoL). The abnormal QOD-NS group had a greater percentage of former smokers compared to the normal group (77.8% vs. 58.1%; P = 0.56) and more median days from surgery compared to the normal group (904 vs. 477 days; P = 0.24). Conclusions: Olfactory dysfunction associated with TL results in blunting of olfactory-specific QoL.

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Total laryngectomy negatively impacts sinonasal and olfactory-specific quality of life

Abstract

Keywords

ASJC Scopus subject areas

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