Total laryngectomy negatively impacts sinonasal and olfactory-specific quality of life

Joy Chen, Roberto N. Solis, Mehrnaz Mehrzad, Amarbir Gill, Beverly Garber, Angela M. Beliveau, Arnaud F. Bewley, Toby O. Steele, Andrew C. Birkeland, Marianne Abouyared

Research output: Contribution to journalArticlepeer-review


Purpose: The purpose of this study is to characterize deficits in olfactory-specific and sinonasal-specific QoL after total laryngectomy (TL) with validated patient reported outcome measures. Methods: Thirty patients who had a TL were prospectively enrolled. Patient demographics, as well as scores from the Questionnaire of Olfactory Disorders Negative Statements (QOD-NS) and the Sino-nasal Outcome Test-22 (SNOT-22) were collected. Univariate analysis was performed to assess associations between patient characteristics and QoL scores. Results: The average QOD-NS score was 37.9 ± 11.4 (<38.5 is considered abnormal) and average SNOT-22 score was 32.0 ± 3.8 (>20 indicates a moderate/severe impact on QoL). The abnormal QOD-NS group had a greater percentage of former smokers compared to the normal group (77.8% vs. 58.1%; P = 0.56) and more median days from surgery compared to the normal group (904 vs. 477 days; P = 0.24). Conclusions: Olfactory dysfunction associated with TL results in blunting of olfactory-specific QoL.

Original languageEnglish (US)
Article number103471
JournalAmerican Journal of Otolaryngology - Head and Neck Medicine and Surgery
Issue number4
StatePublished - Jul 1 2022


  • Head and neck cancer
  • QOD-NS
  • Quality of life
  • SNOT-22
  • Total laryngectomy

ASJC Scopus subject areas

  • Otorhinolaryngology


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