Total homocysteine is associated with white matter hyperintensity volume: The Northern Manhattan study

Clinton B. Wright, Myunghee C. Paik, Truman R. Brown, Sally P. Stabler, Robert H. Allen, Ralph L. Sacco, Charles DeCarli

Research output: Contribution to journalArticle

141 Scopus citations


Background - Total homocysteine (tHcy) has been implicated as a risk factor for stroke and dementia, but the mechanism is unclear. White matter hyperintensities may be a risk factor for both, but studies of the relationship between tHcy and quantitative measures of white matter hyperintensity volume (WMHV) are lacking, especially in minority populations. Methods - A community-based sample of 259 subjects with baseline tHcy levels underwent pixel-based quantitative measurement of WMHV. We examined the relationship between tHcy and WMHV adjusting for age, sociodemographics, vascular risk factors, and B12 deficiency. Results - Higher levels of tHcy were associated with WMHV adjusting for sociodemographics and vascular risk factors. Conclusions - These cross-sectional data provide evidence that tHcy is a risk factor for white matter damage.

Original languageEnglish (US)
Pages (from-to)1207-1211
Number of pages5
Issue number6
StatePublished - Jun 2005



  • Homocysteine
  • Magnetic resonance imaging
  • White matter

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

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