Total homocysteine is associated with white matter hyperintensity volume: The Northern Manhattan study

Clinton B. Wright; Myunghee C. Paik; Truman R. Brown; Sally P. Stabler; Robert H. Allen; Ralph L. Sacco; Charles DeCarli

doi:10.1161/01.STR.0000165923.02318.22

Total homocysteine is associated with white matter hyperintensity volume: The Northern Manhattan study

Clinton B. Wright, Myunghee C. Paik, Truman R. Brown, Sally P. Stabler, Robert H. Allen, Ralph L. Sacco, Charles DeCarli

Neurology

Research output: Contribution to journal › Article › peer-review

146 Scopus citations

Abstract

Background - Total homocysteine (tHcy) has been implicated as a risk factor for stroke and dementia, but the mechanism is unclear. White matter hyperintensities may be a risk factor for both, but studies of the relationship between tHcy and quantitative measures of white matter hyperintensity volume (WMHV) are lacking, especially in minority populations. Methods - A community-based sample of 259 subjects with baseline tHcy levels underwent pixel-based quantitative measurement of WMHV. We examined the relationship between tHcy and WMHV adjusting for age, sociodemographics, vascular risk factors, and B₁₂ deficiency. Results - Higher levels of tHcy were associated with WMHV adjusting for sociodemographics and vascular risk factors. Conclusions - These cross-sectional data provide evidence that tHcy is a risk factor for white matter damage.

Original language	English (US)
Pages (from-to)	1207-1211
Number of pages	5
Journal	Stroke
Volume	36
Issue number	6
DOIs	https://doi.org/10.1161/01.STR.0000165923.02318.22
State	Published - Jun 2005

Keywords

Homocysteine
Magnetic resonance imaging
White matter

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Neuroscience(all)

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10.1161/01.STR.0000165923.02318.22

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title = "Total homocysteine is associated with white matter hyperintensity volume: The Northern Manhattan study",

abstract = "Background - Total homocysteine (tHcy) has been implicated as a risk factor for stroke and dementia, but the mechanism is unclear. White matter hyperintensities may be a risk factor for both, but studies of the relationship between tHcy and quantitative measures of white matter hyperintensity volume (WMHV) are lacking, especially in minority populations. Methods - A community-based sample of 259 subjects with baseline tHcy levels underwent pixel-based quantitative measurement of WMHV. We examined the relationship between tHcy and WMHV adjusting for age, sociodemographics, vascular risk factors, and B12 deficiency. Results - Higher levels of tHcy were associated with WMHV adjusting for sociodemographics and vascular risk factors. Conclusions - These cross-sectional data provide evidence that tHcy is a risk factor for white matter damage.",

keywords = "Homocysteine, Magnetic resonance imaging, White matter",

author = "Wright, {Clinton B.} and Paik, {Myunghee C.} and Brown, {Truman R.} and Stabler, {Sally P.} and Allen, {Robert H.} and Sacco, {Ralph L.} and Charles DeCarli",

year = "2005",

month = jun,

doi = "10.1161/01.STR.0000165923.02318.22",

language = "English (US)",

volume = "36",

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publisher = "Lippincott Williams and Wilkins",

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T1 - Total homocysteine is associated with white matter hyperintensity volume

T2 - The Northern Manhattan study

AU - Wright, Clinton B.

AU - Paik, Myunghee C.

AU - Brown, Truman R.

AU - Stabler, Sally P.

AU - Allen, Robert H.

AU - Sacco, Ralph L.

AU - DeCarli, Charles

PY - 2005/6

Y1 - 2005/6

N2 - Background - Total homocysteine (tHcy) has been implicated as a risk factor for stroke and dementia, but the mechanism is unclear. White matter hyperintensities may be a risk factor for both, but studies of the relationship between tHcy and quantitative measures of white matter hyperintensity volume (WMHV) are lacking, especially in minority populations. Methods - A community-based sample of 259 subjects with baseline tHcy levels underwent pixel-based quantitative measurement of WMHV. We examined the relationship between tHcy and WMHV adjusting for age, sociodemographics, vascular risk factors, and B12 deficiency. Results - Higher levels of tHcy were associated with WMHV adjusting for sociodemographics and vascular risk factors. Conclusions - These cross-sectional data provide evidence that tHcy is a risk factor for white matter damage.

AB - Background - Total homocysteine (tHcy) has been implicated as a risk factor for stroke and dementia, but the mechanism is unclear. White matter hyperintensities may be a risk factor for both, but studies of the relationship between tHcy and quantitative measures of white matter hyperintensity volume (WMHV) are lacking, especially in minority populations. Methods - A community-based sample of 259 subjects with baseline tHcy levels underwent pixel-based quantitative measurement of WMHV. We examined the relationship between tHcy and WMHV adjusting for age, sociodemographics, vascular risk factors, and B12 deficiency. Results - Higher levels of tHcy were associated with WMHV adjusting for sociodemographics and vascular risk factors. Conclusions - These cross-sectional data provide evidence that tHcy is a risk factor for white matter damage.

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KW - Magnetic resonance imaging

KW - White matter

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