Total homocysteine is associated with white matter hyperintensity volume: The Northern Manhattan study

Clinton B. Wright; Myunghee C. Paik; Truman R. Brown; Sally P. Stabler; Robert H. Allen; Ralph L. Sacco; Charles DeCarli

doi:10.1161/01.STR.0000165923.02318.22

Total homocysteine is associated with white matter hyperintensity volume: The Northern Manhattan study

Clinton B. Wright, Myunghee C. Paik, Truman R. Brown, Sally P. Stabler, Robert H. Allen, Ralph L. Sacco, Charles DeCarli

Neurology

Research output: Contribution to journal › Article

141 Scopus citations

Abstract

Background - Total homocysteine (tHcy) has been implicated as a risk factor for stroke and dementia, but the mechanism is unclear. White matter hyperintensities may be a risk factor for both, but studies of the relationship between tHcy and quantitative measures of white matter hyperintensity volume (WMHV) are lacking, especially in minority populations. Methods - A community-based sample of 259 subjects with baseline tHcy levels underwent pixel-based quantitative measurement of WMHV. We examined the relationship between tHcy and WMHV adjusting for age, sociodemographics, vascular risk factors, and B₁₂ deficiency. Results - Higher levels of tHcy were associated with WMHV adjusting for sociodemographics and vascular risk factors. Conclusions - These cross-sectional data provide evidence that tHcy is a risk factor for white matter damage.

Original language	English (US)
Pages (from-to)	1207-1211
Number of pages	5
Journal	Stroke
Volume	36
Issue number	6
DOIs	https://doi.org/10.1161/01.STR.0000165923.02318.22
State	Published - Jun 2005

Fingerprint

Keywords

Homocysteine
Magnetic resonance imaging
White matter

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Neuroscience(all)

Cite this

Wright, C. B., Paik, M. C., Brown, T. R., Stabler, S. P., Allen, R. H., Sacco, R. L., & DeCarli, C. (2005). Total homocysteine is associated with white matter hyperintensity volume: The Northern Manhattan study. Stroke, 36(6), 1207-1211. https://doi.org/10.1161/01.STR.0000165923.02318.22

@article{87c69f2ef95043f1aef1e90c7a624a74,

title = "Total homocysteine is associated with white matter hyperintensity volume: The Northern Manhattan study",

abstract = "Background - Total homocysteine (tHcy) has been implicated as a risk factor for stroke and dementia, but the mechanism is unclear. White matter hyperintensities may be a risk factor for both, but studies of the relationship between tHcy and quantitative measures of white matter hyperintensity volume (WMHV) are lacking, especially in minority populations. Methods - A community-based sample of 259 subjects with baseline tHcy levels underwent pixel-based quantitative measurement of WMHV. We examined the relationship between tHcy and WMHV adjusting for age, sociodemographics, vascular risk factors, and B12 deficiency. Results - Higher levels of tHcy were associated with WMHV adjusting for sociodemographics and vascular risk factors. Conclusions - These cross-sectional data provide evidence that tHcy is a risk factor for white matter damage.",

keywords = "Homocysteine, Magnetic resonance imaging, White matter",

author = "Wright, {Clinton B.} and Paik, {Myunghee C.} and Brown, {Truman R.} and Stabler, {Sally P.} and Allen, {Robert H.} and Sacco, {Ralph L.} and Charles DeCarli",

year = "2005",

month = jun

doi = "10.1161/01.STR.0000165923.02318.22",

language = "English (US)",

volume = "36",

pages = "1207--1211",

journal = "Stroke",

issn = "0039-2499",

publisher = "Lippincott Williams and Wilkins",

number = "6",

}

TY - JOUR

T1 - Total homocysteine is associated with white matter hyperintensity volume

T2 - The Northern Manhattan study

AU - Wright, Clinton B.

AU - Paik, Myunghee C.

AU - Brown, Truman R.

AU - Stabler, Sally P.

AU - Allen, Robert H.

AU - Sacco, Ralph L.

AU - DeCarli, Charles

PY - 2005/6

Y1 - 2005/6

N2 - Background - Total homocysteine (tHcy) has been implicated as a risk factor for stroke and dementia, but the mechanism is unclear. White matter hyperintensities may be a risk factor for both, but studies of the relationship between tHcy and quantitative measures of white matter hyperintensity volume (WMHV) are lacking, especially in minority populations. Methods - A community-based sample of 259 subjects with baseline tHcy levels underwent pixel-based quantitative measurement of WMHV. We examined the relationship between tHcy and WMHV adjusting for age, sociodemographics, vascular risk factors, and B12 deficiency. Results - Higher levels of tHcy were associated with WMHV adjusting for sociodemographics and vascular risk factors. Conclusions - These cross-sectional data provide evidence that tHcy is a risk factor for white matter damage.

AB - Background - Total homocysteine (tHcy) has been implicated as a risk factor for stroke and dementia, but the mechanism is unclear. White matter hyperintensities may be a risk factor for both, but studies of the relationship between tHcy and quantitative measures of white matter hyperintensity volume (WMHV) are lacking, especially in minority populations. Methods - A community-based sample of 259 subjects with baseline tHcy levels underwent pixel-based quantitative measurement of WMHV. We examined the relationship between tHcy and WMHV adjusting for age, sociodemographics, vascular risk factors, and B12 deficiency. Results - Higher levels of tHcy were associated with WMHV adjusting for sociodemographics and vascular risk factors. Conclusions - These cross-sectional data provide evidence that tHcy is a risk factor for white matter damage.

KW - Homocysteine

KW - Magnetic resonance imaging

KW - White matter

UR - http://www.scopus.com/inward/record.url?scp=20444410004&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20444410004&partnerID=8YFLogxK

U2 - 10.1161/01.STR.0000165923.02318.22

DO - 10.1161/01.STR.0000165923.02318.22

M3 - Article

C2 - 15879345

AN - SCOPUS:20444410004

VL - 36

SP - 1207

EP - 1211

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 6

ER -

Access to Document

10.1161/01.STR.0000165923.02318.22