Total Gastrectomy for Hereditary Diffuse Gastric Cancer at a Single Center

Vivian E. Strong, Sepideh Gholami, Manish A. Shah, Laura H. Tang, Yelena Y. Janjigian, Mark Schattner, Luke V. Selby, Sam S. Yoon, Erin Salo-Mullen, Zsofia K. Stadler, David Kelsen, Murray F. Brennan, Daniel G. Coit

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective: The aim of this study was to describe postoperative outcomes of total gastrectomy at our institution for patients with hereditary diffuse gastric cancer (HDGC). Background: HDGC, which is mainly caused by germline mutations in the E-cadherin gene (CDH1), renders a lifetime risk of gastric cancer of up to 70%, prompting a recommendation for prophylactic total gastrectomy. Methods: A prospective gastric cancer database identified 41 patients with CDH1 mutation who underwent total gastrectomy during 2005 to 2015. Perioperative, histopathologic, and long-term data were collected. Results: Of the 41 patients undergoing total gastrectomy, median age was 47 years (range 20 to 71). There were 14 men and 27 women, with 25 open operations and 16 minimally invasive operations. Median length of stay was 7 days (range 4 to 50). In total, 11 patients (27%) experienced a complication requiring intervention, and there was 1 peri-operative mortality (2.5%). Thirty-five patients (85%) demonstrated 1 or more foci of intramucosal signet ring cell gastric cancer in the examined specimen. At 16 months median follow-up, the median weight loss was 4.7kg (15% of preoperative weight). By 6 to 12 months postoperatively, weight patterns stabilized. Overall outcome was reported to be "as expected" by 40% of patients and "better than expected" by 45%. Patient-reported outcomes were similar to those of other patients undergoing total gastrectomy. Conclusion: Total gastrectomy should be considered for all CDH1 mutation carriers because of the high risk of invasive diffuse-type gastric cancer and lack of reliable surveillance options. Although most patients have durable weight loss after total gastrectomy, weights stabilize at about 6 to 12 months postoperatively, and patients report outcomes as being good to better than their preoperative expectations. No patients have developed gastric cancer recurrence after resections.

Original languageEnglish (US)
Pages (from-to)1006-1012
Number of pages7
JournalAnnals of Surgery
Volume266
Issue number6
DOIs
StatePublished - Dec 1 2017
Externally publishedYes

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Gastrectomy
Stomach Neoplasms
Weights and Measures
Weight Loss
Mutation
Germ-Line Mutation
Cadherins
Length of Stay
Databases
Recurrence
Mortality

Keywords

  • gastrectomy
  • gastric cancer
  • postoperative weight loss
  • prophylactic surgery

ASJC Scopus subject areas

  • Surgery

Cite this

Strong, V. E., Gholami, S., Shah, M. A., Tang, L. H., Janjigian, Y. Y., Schattner, M., ... Coit, D. G. (2017). Total Gastrectomy for Hereditary Diffuse Gastric Cancer at a Single Center. Annals of Surgery, 266(6), 1006-1012. https://doi.org/10.1097/SLA.0000000000002030

Total Gastrectomy for Hereditary Diffuse Gastric Cancer at a Single Center. / Strong, Vivian E.; Gholami, Sepideh; Shah, Manish A.; Tang, Laura H.; Janjigian, Yelena Y.; Schattner, Mark; Selby, Luke V.; Yoon, Sam S.; Salo-Mullen, Erin; Stadler, Zsofia K.; Kelsen, David; Brennan, Murray F.; Coit, Daniel G.

In: Annals of Surgery, Vol. 266, No. 6, 01.12.2017, p. 1006-1012.

Research output: Contribution to journalArticle

Strong, VE, Gholami, S, Shah, MA, Tang, LH, Janjigian, YY, Schattner, M, Selby, LV, Yoon, SS, Salo-Mullen, E, Stadler, ZK, Kelsen, D, Brennan, MF & Coit, DG 2017, 'Total Gastrectomy for Hereditary Diffuse Gastric Cancer at a Single Center', Annals of Surgery, vol. 266, no. 6, pp. 1006-1012. https://doi.org/10.1097/SLA.0000000000002030
Strong, Vivian E. ; Gholami, Sepideh ; Shah, Manish A. ; Tang, Laura H. ; Janjigian, Yelena Y. ; Schattner, Mark ; Selby, Luke V. ; Yoon, Sam S. ; Salo-Mullen, Erin ; Stadler, Zsofia K. ; Kelsen, David ; Brennan, Murray F. ; Coit, Daniel G. / Total Gastrectomy for Hereditary Diffuse Gastric Cancer at a Single Center. In: Annals of Surgery. 2017 ; Vol. 266, No. 6. pp. 1006-1012.
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