Total-body PET Imaging: A New Frontier for the Assessment of Metabolic Disease and Obesity

Maria Chondronikola; Souvik Sarkar

doi:10.1016/j.cpet.2020.09.001

Total-body PET Imaging: A New Frontier for the Assessment of Metabolic Disease and Obesity

Maria Chondronikola, Souvik Sarkar

Gastroenterology and Hepatology

Research output: Contribution to journal › Review article › peer-review

Abstract

Obesity and associated metabolic syndrome are a global public health issue. Understanding the pathophysiology of this systemic disease is of critical importance for the development of future therapeutic interventions to improve clinical outcomes. The multiorgan nature of the pathophysiology of obesity presents a unique challenge. Total-body PET imaging, either static or dynamic, provides a vital set of tools to study organ crosstalk. The visualization and quantification of tissue metabolic kinetics with total-body PET in health and disease provides essential information to better understand disease physiology and potentially develop diagnostic and therapeutic modalities.

Original language	English (US)
Journal	PET Clinics
DOIs	https://doi.org/10.1016/j.cpet.2020.09.001
State	Accepted/In press - 2020

Keywords

Adipose tissue
Metabolic syndrome
Nonalcoholic fatty liver disease
PET
Skeletal muscle

ASJC Scopus subject areas

Radiation
Radiology Nuclear Medicine and imaging

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title = "Total-body PET Imaging: A New Frontier for the Assessment of Metabolic Disease and Obesity",

abstract = "Obesity and associated metabolic syndrome are a global public health issue. Understanding the pathophysiology of this systemic disease is of critical importance for the development of future therapeutic interventions to improve clinical outcomes. The multiorgan nature of the pathophysiology of obesity presents a unique challenge. Total-body PET imaging, either static or dynamic, provides a vital set of tools to study organ crosstalk. The visualization and quantification of tissue metabolic kinetics with total-body PET in health and disease provides essential information to better understand disease physiology and potentially develop diagnostic and therapeutic modalities.",

keywords = "Adipose tissue, Metabolic syndrome, Nonalcoholic fatty liver disease, PET, Skeletal muscle",

author = "Maria Chondronikola and Souvik Sarkar",

note = "Funding Information: Dr. Chondronikola is supported by the by the National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), through grant UL1 TR001860 and the USDA National Institute of Food and Agriculture, Hatch project number CA-D-NTR-2618-H.",

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language = "English (US)",

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AU - Sarkar, Souvik

N1 - Funding Information: Dr. Chondronikola is supported by the by the National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), through grant UL1 TR001860 and the USDA National Institute of Food and Agriculture, Hatch project number CA-D-NTR-2618-H.

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N2 - Obesity and associated metabolic syndrome are a global public health issue. Understanding the pathophysiology of this systemic disease is of critical importance for the development of future therapeutic interventions to improve clinical outcomes. The multiorgan nature of the pathophysiology of obesity presents a unique challenge. Total-body PET imaging, either static or dynamic, provides a vital set of tools to study organ crosstalk. The visualization and quantification of tissue metabolic kinetics with total-body PET in health and disease provides essential information to better understand disease physiology and potentially develop diagnostic and therapeutic modalities.

AB - Obesity and associated metabolic syndrome are a global public health issue. Understanding the pathophysiology of this systemic disease is of critical importance for the development of future therapeutic interventions to improve clinical outcomes. The multiorgan nature of the pathophysiology of obesity presents a unique challenge. Total-body PET imaging, either static or dynamic, provides a vital set of tools to study organ crosstalk. The visualization and quantification of tissue metabolic kinetics with total-body PET in health and disease provides essential information to better understand disease physiology and potentially develop diagnostic and therapeutic modalities.

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KW - Nonalcoholic fatty liver disease

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