Topographical analysis of nucleus accumbens sites at which cholecystokinin potentiates dopamine-induced hyperlocomotion in the rat

Jacqueline Crawley, D. W. Hommer, L. R. Skirboll

Research output: Contribution to journalArticle

83 Scopus citations

Abstract

Sulfated cholecystokinin octapeptide (CCK) potentiates dopamine-induced hyperlocomotion in the nucleus accumbens of the rat. Immunocytochemical evidence has shown a topographical distribution of terminals containing both CCK and dopamine (DA), within the medial posterior nucleus accumbens. Seven sites within the nucleus accumbens were cannulated and tested for the ability of CCK to enhance the behavioral effects of DA. Close agreement was found between the anatomical sites of CCK-DA coexistence, and the anatomical sites at which CCK potentiated DA-induced hyperlocomotion. Behaviorally inactive sites were found primarily in the anterior nucleus accumbens, where DA-containing terminals do not contain CCK.

Original languageEnglish (US)
Pages (from-to)337-341
Number of pages5
JournalBrain Research
Volume335
Issue number2
DOIs
StatePublished - Jun 3 1985
Externally publishedYes

Keywords

  • anatomy
  • cholecystokinin
  • coexistence
  • dopamine
  • locomotion
  • nucleus accumbens
  • topography

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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