Topographic distribution of bcl-2 protein in feline tissues in health and neoplasia

B. R. Madewell, Regina F Gandour-Edwards, B. F. Edwards, J. E. Walls, Stephen M Griffey

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The bcl-2 family of genes encodes proteins that influence apoptosis. In the present immunohis-tochemical study, the topographic distribution of bcl-2 protein was examined in healthy feline fetal, neonatal, and adult tissues, a feline renal cell line, and feline tumors obtained from a veterinary hospital. The topographic distribution of bcl-2 in healthy tissues was similar to that described in human tissues. In lymphoid tissues, follicular mantle cells strongly expressed bcl-2. In complex and differentiating epithelium, bcl-2 expression was detected in stem cell and proliferation zones. Bcl-2 expression was also detected in lower crypts of the intestine and in skin basal layers. The feline Crandell kidney cells expressed bcl-2 diffusely throughout the cytoplasm. Of 180 tumors examined, bcl-2 was expressed almost uniformly in cutaneous basal cell tumors, thyroid adenomas, and mammary carcinomas and in 50% of the lymphomas examined. Bcl-2 may play a role in blocking apoptotic cell death in a broad range of normal feline tissues, whereas dysregulated bcl-2 may extend the life of certain tumors or render certain tumors resistant to therapy because most chemotherapeutic and radiotherapeutic agents eliminate tumor cells by triggering apoptosis.

Original languageEnglish (US)
Pages (from-to)565-573
Number of pages9
JournalVeterinary Pathology
Volume36
Issue number6
StatePublished - 1999

Keywords

  • Bcl-2 oncoprotein
  • Cats
  • Neoplasms
  • Normal tissues

ASJC Scopus subject areas

  • veterinary(all)

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