Topical therapeutic agents that modulate corneal wound healing

Ellison Bentley, Christopher J Murphy

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


In summary, corneal wound healing is a complex phenomenon that involves interplay between the cellular elements of the cornea, numerous soluble factors, and the constituents of the ECM. Unfortunately, many studies that demonstrate marked alteration on cell behavior in vitro and even in in vivo experiments are often not helpful in the diseased patient, asshown by the results of careful clinical trials. Future work that addresses the complex milieu of the corneal wound healing environment by addressing the interaction of many of these factors will be more likely to be successful than seeking a single agent that will enhance wound healing in all situations. Modulation of wound healing processes by the application of topical therapeutic agents is, however, an expanding field of study sure to produce clinically significant improvements in the management of veterinary patients with corneal defects. The judicious use of topical cytoactive compounds hasa place in the clinician's armamentarium integrated into a therapeutic plan that decreases the mechanical stresses imposed on the wound bed as well asremoval of any underlying inciting cause.

Original languageEnglish (US)
Pages (from-to)623-638
Number of pages16
JournalVeterinary Clinics of North America - Small Animal Practice
Issue number3
StatePublished - May 2004
Externally publishedYes

ASJC Scopus subject areas

  • veterinary(all)


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