Abstract
The optimal management of anthracycline extravasation remains unclear. Traditional topical measures to reduce local tissue damage, including corticosteroids, sodium bicarbonate, and ice applications, have not consistently demonstrated beneficial effects. This report describes our experience with four adult patients who suffered anthracycline extravasation and were treated with a regimen of ice, local glucocorticoid injection, and dimethylsulfoxide (DMSO) 55%-99% applied topically every 2-4h after extravasation for a minimum of 3 days. In all four cases, pain and erythema resolved within 2 days; in no case did tissue necrosis or skin ulceration occur. Topical DMSO is a safe, inexpensive agent that appears to reduce the risk of anthracycline-induced tissue damage. Further studies are needed to determine the optimal dose and schedule of DMSO application and to assess its efficacy in extravasation injuries from other vesicants.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 316-318 |
| Number of pages | 3 |
| Journal | Cancer Chemotherapy and Pharmacology |
| Volume | 23 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1989 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmacology
- Oncology
- Cancer Research
Cite this
Topical dimethylsulfoxide may prevent tissue damage from anthracycline extravasation. / Lawrence, H. Jeffrey; Walsh, Denise; Zapotowski, Karen A.; Denham, Alice; Goodnight, Scott H.; Gandara, David R.
In: Cancer Chemotherapy and Pharmacology, Vol. 23, No. 5, 05.1989, p. 316-318.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Topical dimethylsulfoxide may prevent tissue damage from anthracycline extravasation
AU - Lawrence, H. Jeffrey
AU - Walsh, Denise
AU - Zapotowski, Karen A.
AU - Denham, Alice
AU - Goodnight, Scott H.
AU - Gandara, David R
PY - 1989/5
Y1 - 1989/5
N2 - The optimal management of anthracycline extravasation remains unclear. Traditional topical measures to reduce local tissue damage, including corticosteroids, sodium bicarbonate, and ice applications, have not consistently demonstrated beneficial effects. This report describes our experience with four adult patients who suffered anthracycline extravasation and were treated with a regimen of ice, local glucocorticoid injection, and dimethylsulfoxide (DMSO) 55%-99% applied topically every 2-4h after extravasation for a minimum of 3 days. In all four cases, pain and erythema resolved within 2 days; in no case did tissue necrosis or skin ulceration occur. Topical DMSO is a safe, inexpensive agent that appears to reduce the risk of anthracycline-induced tissue damage. Further studies are needed to determine the optimal dose and schedule of DMSO application and to assess its efficacy in extravasation injuries from other vesicants.
AB - The optimal management of anthracycline extravasation remains unclear. Traditional topical measures to reduce local tissue damage, including corticosteroids, sodium bicarbonate, and ice applications, have not consistently demonstrated beneficial effects. This report describes our experience with four adult patients who suffered anthracycline extravasation and were treated with a regimen of ice, local glucocorticoid injection, and dimethylsulfoxide (DMSO) 55%-99% applied topically every 2-4h after extravasation for a minimum of 3 days. In all four cases, pain and erythema resolved within 2 days; in no case did tissue necrosis or skin ulceration occur. Topical DMSO is a safe, inexpensive agent that appears to reduce the risk of anthracycline-induced tissue damage. Further studies are needed to determine the optimal dose and schedule of DMSO application and to assess its efficacy in extravasation injuries from other vesicants.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024582660&partnerID=8YFLogxK
U2 - 10.1007/BF00292411
DO - 10.1007/BF00292411
M3 - Article
C2 - 2706738
AN - SCOPUS:0024582660
VL - 23
SP - 316
EP - 318
JO - Cancer Chemotherapy and Pharmacology
JF - Cancer Chemotherapy and Pharmacology
SN - 0344-5704
IS - 5
ER -