Topical dimethylsulfoxide may prevent tissue damage from anthracycline extravasation

H. Jeffrey Lawrence, Denise Walsh, Karen A. Zapotowski, Alice Denham, Scott H. Goodnight, David R Gandara

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The optimal management of anthracycline extravasation remains unclear. Traditional topical measures to reduce local tissue damage, including corticosteroids, sodium bicarbonate, and ice applications, have not consistently demonstrated beneficial effects. This report describes our experience with four adult patients who suffered anthracycline extravasation and were treated with a regimen of ice, local glucocorticoid injection, and dimethylsulfoxide (DMSO) 55%-99% applied topically every 2-4h after extravasation for a minimum of 3 days. In all four cases, pain and erythema resolved within 2 days; in no case did tissue necrosis or skin ulceration occur. Topical DMSO is a safe, inexpensive agent that appears to reduce the risk of anthracycline-induced tissue damage. Further studies are needed to determine the optimal dose and schedule of DMSO application and to assess its efficacy in extravasation injuries from other vesicants.

Original languageEnglish (US)
Pages (from-to)316-318
Number of pages3
JournalCancer Chemotherapy and Pharmacology
Volume23
Issue number5
DOIs
StatePublished - May 1989
Externally publishedYes

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Anthracyclines
Dimethyl Sulfoxide
Ice
Tissue
Sodium Bicarbonate
Irritants
Erythema
Glucocorticoids
Skin
Appointments and Schedules
Adrenal Cortex Hormones
Necrosis
Pain
Injections
Wounds and Injuries

ASJC Scopus subject areas

  • Pharmacology
  • Oncology
  • Cancer Research

Cite this

Topical dimethylsulfoxide may prevent tissue damage from anthracycline extravasation. / Lawrence, H. Jeffrey; Walsh, Denise; Zapotowski, Karen A.; Denham, Alice; Goodnight, Scott H.; Gandara, David R.

In: Cancer Chemotherapy and Pharmacology, Vol. 23, No. 5, 05.1989, p. 316-318.

Research output: Contribution to journalArticle

Lawrence, H. Jeffrey ; Walsh, Denise ; Zapotowski, Karen A. ; Denham, Alice ; Goodnight, Scott H. ; Gandara, David R. / Topical dimethylsulfoxide may prevent tissue damage from anthracycline extravasation. In: Cancer Chemotherapy and Pharmacology. 1989 ; Vol. 23, No. 5. pp. 316-318.
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