Toll-like receptors (TLRs) are newly established immune receptors which are critical for host defense through the activation of both innate and adaptive immunity. TLRs can recognize molecules with both microbial and non-microbial origins. Emerging evidence now suggests that TLRs are implicated in the pathogenesis of many chronic diseases, including sepsis, atherosclerosis, ischemia/reperfusion-mediated organ dysfunction, rheumatoid arthritis, diabetes, and cancer. Therefore, an understanding of the role of TLRs in inducing chronic inflammation will provide new insights to help design an effective intervention strategy for inflammatory diseases.
- Myeloid differentiation factor 88
- Toll-like receptors
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine
- Critical Care
- Molecular Biology