Tissue Tropism in Host Transcriptional Response to Members of the Bovine Respiratory Disease Complex

Susanta K. Behura, Polyana C. Tizioto, Jaewoo Kim, Natalia V. Grupioni, Christopher M. Seabury, Robert D. Schnabel, Laurel J Gershwin, Alison L. Van Eenennaam, Rachel Toaff-Rosenstein, Holly L. Neibergs, Luciana C.A. Regitano, Jeremy F. Taylor

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Bovine respiratory disease (BRD) is the most common infectious disease of beef and dairy cattle and is characterized by a complex infectious etiology that includes a variety of viral and bacterial pathogens. We examined the global changes in mRNA abundance in healthy lung and lung lesions and in the lymphoid tissues bronchial lymph node, retropharyngeal lymph node, nasopharyngeal lymph node and pharyngeal tonsil collected at the peak of clinical disease from beef cattle experimentally challenged with either bovine respiratory syncytial virus, infectious bovine rhinotracheitis, bovine viral diarrhea virus, Mannheimia haemolytica or Mycoplasma bovis. We identified signatures of tissue-specific transcriptional responses indicative of tropism in the coordination of host's immune tissue responses to infection by viral or bacterial infections. Furthermore, our study shows that this tissue tropism in host transcriptional response to BRD pathogens results in the activation of different networks of response genes. The differential crosstalk among genes expressed in lymphoid tissues was predicted to be orchestrated by specific immune genes that act as 'key players' within expression networks. The results of this study serve as a basis for the development of innovative therapeutic strategies and for the selection of cattle with enhanced resistance to BRD.

Original languageEnglish (US)
Article number17938
JournalScientific Reports
Volume7
Issue number1
DOIs
StatePublished - Dec 1 2017

Fingerprint

Bovine Respiratory Disease Complex
Viral Tropism
Cattle Diseases
Lymph Nodes
Lymphoid Tissue
Mycoplasma bovis
Infectious Bovine Rhinotracheitis
Bovine respiratory syncytial virus
Mannheimia haemolytica
Bovine Viral Diarrhea Viruses
Adenoids
Lung
Tropism
Gene Regulatory Networks
Virus Diseases
Bacterial Infections
Genes
Communicable Diseases
Messenger RNA
Infection

ASJC Scopus subject areas

  • General

Cite this

Behura, S. K., Tizioto, P. C., Kim, J., Grupioni, N. V., Seabury, C. M., Schnabel, R. D., ... Taylor, J. F. (2017). Tissue Tropism in Host Transcriptional Response to Members of the Bovine Respiratory Disease Complex. Scientific Reports, 7(1), [17938]. https://doi.org/10.1038/s41598-017-18205-0

Tissue Tropism in Host Transcriptional Response to Members of the Bovine Respiratory Disease Complex. / Behura, Susanta K.; Tizioto, Polyana C.; Kim, Jaewoo; Grupioni, Natalia V.; Seabury, Christopher M.; Schnabel, Robert D.; Gershwin, Laurel J; Van Eenennaam, Alison L.; Toaff-Rosenstein, Rachel; Neibergs, Holly L.; Regitano, Luciana C.A.; Taylor, Jeremy F.

In: Scientific Reports, Vol. 7, No. 1, 17938, 01.12.2017.

Research output: Contribution to journalArticle

Behura, SK, Tizioto, PC, Kim, J, Grupioni, NV, Seabury, CM, Schnabel, RD, Gershwin, LJ, Van Eenennaam, AL, Toaff-Rosenstein, R, Neibergs, HL, Regitano, LCA & Taylor, JF 2017, 'Tissue Tropism in Host Transcriptional Response to Members of the Bovine Respiratory Disease Complex', Scientific Reports, vol. 7, no. 1, 17938. https://doi.org/10.1038/s41598-017-18205-0
Behura, Susanta K. ; Tizioto, Polyana C. ; Kim, Jaewoo ; Grupioni, Natalia V. ; Seabury, Christopher M. ; Schnabel, Robert D. ; Gershwin, Laurel J ; Van Eenennaam, Alison L. ; Toaff-Rosenstein, Rachel ; Neibergs, Holly L. ; Regitano, Luciana C.A. ; Taylor, Jeremy F. / Tissue Tropism in Host Transcriptional Response to Members of the Bovine Respiratory Disease Complex. In: Scientific Reports. 2017 ; Vol. 7, No. 1.
@article{f21e7890225645ba96025af104a87c4f,
title = "Tissue Tropism in Host Transcriptional Response to Members of the Bovine Respiratory Disease Complex",
abstract = "Bovine respiratory disease (BRD) is the most common infectious disease of beef and dairy cattle and is characterized by a complex infectious etiology that includes a variety of viral and bacterial pathogens. We examined the global changes in mRNA abundance in healthy lung and lung lesions and in the lymphoid tissues bronchial lymph node, retropharyngeal lymph node, nasopharyngeal lymph node and pharyngeal tonsil collected at the peak of clinical disease from beef cattle experimentally challenged with either bovine respiratory syncytial virus, infectious bovine rhinotracheitis, bovine viral diarrhea virus, Mannheimia haemolytica or Mycoplasma bovis. We identified signatures of tissue-specific transcriptional responses indicative of tropism in the coordination of host's immune tissue responses to infection by viral or bacterial infections. Furthermore, our study shows that this tissue tropism in host transcriptional response to BRD pathogens results in the activation of different networks of response genes. The differential crosstalk among genes expressed in lymphoid tissues was predicted to be orchestrated by specific immune genes that act as 'key players' within expression networks. The results of this study serve as a basis for the development of innovative therapeutic strategies and for the selection of cattle with enhanced resistance to BRD.",
author = "Behura, {Susanta K.} and Tizioto, {Polyana C.} and Jaewoo Kim and Grupioni, {Natalia V.} and Seabury, {Christopher M.} and Schnabel, {Robert D.} and Gershwin, {Laurel J} and {Van Eenennaam}, {Alison L.} and Rachel Toaff-Rosenstein and Neibergs, {Holly L.} and Regitano, {Luciana C.A.} and Taylor, {Jeremy F.}",
year = "2017",
month = "12",
day = "1",
doi = "10.1038/s41598-017-18205-0",
language = "English (US)",
volume = "7",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Tissue Tropism in Host Transcriptional Response to Members of the Bovine Respiratory Disease Complex

AU - Behura, Susanta K.

AU - Tizioto, Polyana C.

AU - Kim, Jaewoo

AU - Grupioni, Natalia V.

AU - Seabury, Christopher M.

AU - Schnabel, Robert D.

AU - Gershwin, Laurel J

AU - Van Eenennaam, Alison L.

AU - Toaff-Rosenstein, Rachel

AU - Neibergs, Holly L.

AU - Regitano, Luciana C.A.

AU - Taylor, Jeremy F.

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Bovine respiratory disease (BRD) is the most common infectious disease of beef and dairy cattle and is characterized by a complex infectious etiology that includes a variety of viral and bacterial pathogens. We examined the global changes in mRNA abundance in healthy lung and lung lesions and in the lymphoid tissues bronchial lymph node, retropharyngeal lymph node, nasopharyngeal lymph node and pharyngeal tonsil collected at the peak of clinical disease from beef cattle experimentally challenged with either bovine respiratory syncytial virus, infectious bovine rhinotracheitis, bovine viral diarrhea virus, Mannheimia haemolytica or Mycoplasma bovis. We identified signatures of tissue-specific transcriptional responses indicative of tropism in the coordination of host's immune tissue responses to infection by viral or bacterial infections. Furthermore, our study shows that this tissue tropism in host transcriptional response to BRD pathogens results in the activation of different networks of response genes. The differential crosstalk among genes expressed in lymphoid tissues was predicted to be orchestrated by specific immune genes that act as 'key players' within expression networks. The results of this study serve as a basis for the development of innovative therapeutic strategies and for the selection of cattle with enhanced resistance to BRD.

AB - Bovine respiratory disease (BRD) is the most common infectious disease of beef and dairy cattle and is characterized by a complex infectious etiology that includes a variety of viral and bacterial pathogens. We examined the global changes in mRNA abundance in healthy lung and lung lesions and in the lymphoid tissues bronchial lymph node, retropharyngeal lymph node, nasopharyngeal lymph node and pharyngeal tonsil collected at the peak of clinical disease from beef cattle experimentally challenged with either bovine respiratory syncytial virus, infectious bovine rhinotracheitis, bovine viral diarrhea virus, Mannheimia haemolytica or Mycoplasma bovis. We identified signatures of tissue-specific transcriptional responses indicative of tropism in the coordination of host's immune tissue responses to infection by viral or bacterial infections. Furthermore, our study shows that this tissue tropism in host transcriptional response to BRD pathogens results in the activation of different networks of response genes. The differential crosstalk among genes expressed in lymphoid tissues was predicted to be orchestrated by specific immune genes that act as 'key players' within expression networks. The results of this study serve as a basis for the development of innovative therapeutic strategies and for the selection of cattle with enhanced resistance to BRD.

UR - http://www.scopus.com/inward/record.url?scp=85038879112&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85038879112&partnerID=8YFLogxK

U2 - 10.1038/s41598-017-18205-0

DO - 10.1038/s41598-017-18205-0

M3 - Article

C2 - 29263411

AN - SCOPUS:85038879112

VL - 7

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 17938

ER -