Tissue tropism and promoter sequence variation in caprine arthritis encephalitis virus infected goats

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Caprine arthritis encephalitis virus is a lentivirus that infects goats and is closely related to maedi-visna virus of sheep. Infection with CAEV results in multiple discrete disease manifestations in goats which can include chronic arthritis, mastitis, pneumonia or encephalomyelitis. Presently, no satisfactory mechanistic rationale for viral tropism has been put forward. We propose that specific sequences in the lentiviral promoter (U3 region of the viral long terminal repeat) are associated with viral tissue tropism and subsequent disease expression. A total of 41 distinct CAE viral promoter regions were amplified, sequenced and phylogenetically compared from the tissues of 24 CAEV-infected goats demonstrating a variety of disease manifestations. Phylogenetically, we identified no tendency for clustering of these promoter sequences into tissue-specific groups. These results therefore do not provide evidence for the study hypothesis. However, multiple motifs within the U3 promoter region were highly conserved both within the entire collection of sequences and within tissue-specific groups.

Original languageEnglish (US)
Pages (from-to)177-184
Number of pages8
JournalVirus Research
Volume151
Issue number2
DOIs
StatePublished - Aug 2010

Keywords

  • Caprine arthritis encephalitis virus (CAEV)
  • Goat
  • Lentivirus
  • Promoter
  • SRLV
  • Tissue tropism

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases
  • Cancer Research
  • Medicine(all)

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