Abstract
Ca2+ influx through the L-type Ca2+ channel Cav1.2 triggers each heartbeat. The fight-or-flight response induces the release of the stress response hormone norepinephrine to stimulate β-adrenergic receptors, cAMP production, and protein kinase A activity to augment Ca2+ influx through Cav1.2 and, consequently, cardiomyocyte contractility. Emerging evidence shows that Cav1.2 is regulated by different mechanisms in cardiomyocytes compared to neurons and vascular smooth muscle cells.
Original language | English (US) |
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Article number | ABC6438 |
Journal | Science Signaling |
Volume | 13 |
Issue number | 663 |
DOIs | |
State | Published - Dec 22 2020 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology