Tissue-specific adrenergic regulation of the L-type Ca2+ channel CaV1.2

Kwun Nok Mimi Man, Peter Bartels, Mary C Horne, Johannes W. Hell

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Ca2+ influx through the L-type Ca2+ channel Cav1.2 triggers each heartbeat. The fight-or-flight response induces the release of the stress response hormone norepinephrine to stimulate β-adrenergic receptors, cAMP production, and protein kinase A activity to augment Ca2+ influx through Cav1.2 and, consequently, cardiomyocyte contractility. Emerging evidence shows that Cav1.2 is regulated by different mechanisms in cardiomyocytes compared to neurons and vascular smooth muscle cells.

Original languageEnglish (US)
Article numberABC6438
JournalScience Signaling
Volume13
Issue number663
DOIs
StatePublished - Dec 22 2020

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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