Tissue Pharmacologic and Virologic Determinants of Duodenal and Rectal Gastrointestinal-Associated Lymphoid Tissue Immune Reconstitution in HIV-Infected Patients Initiating Antiretroviral Therapy

David Asmuth, Corbin G. Thompson, Tae Wook Chun, Zhong Min Ma, Surinder K Mann, Talia Sainz, Sergio Serrano-Villar, Netanya S. Utay, Juan Carlos Garcia, Paolo Troia-Cancio, Richard B Pollard, Chris J Miller, Alan Landay, Angela D. Kashuba

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Plasma, duodenal, and rectal tissue antiretroviral therapy (ART) drug concentrations, human immunodeficiency virus (HIV) RNA and HIV DNA copy numbers, and recovery of mucosal immunity were measured before and 9 months after initiation of 3 different ART regimens in 26 subjects. Plasma and tissue HIV RNA correlated at baseline and when 9-month declines were compared, suggesting that these compartments are tightly associated. Antiretroviral tissue:blood penetration ratios were above the 50% inhibitory concentration values in almost 100% of cases. There were no correlations between drug concentrations and HIV DNA/RNA. Importantly, no evidence was found for residual viral replication or deficient tissue drug penetration to account for delayed gastrointestinal-associated lymphoid tissue immune recovery.

Original languageEnglish (US)
Pages (from-to)813-818
Number of pages6
JournalJournal of Infectious Diseases
Volume216
Issue number7
DOIs
StatePublished - Jan 1 2017

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Keywords

  • antiretroviral concentration
  • ART tissue penetration
  • gastrointestinal-associated lymphoid tissue
  • HIV persistence
  • immune reconstitution

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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