Tissue injury in marrow transdifferentiation

Mehrdad Abedi, D. A. Greer, G. A. Colvin, D. A. Demers, M. S. Dooner, J. A. Harpel, J. Pimentel, M. K. Menon, P. J. Quesenberry

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Recent findings indicate that adult BM contains cells that can differentiate into mature, nonhematopoietic cells of multiple tissues including cells of the kidney, lung, liver, skin and GI tract and fibers of heart and skeletal muscle. Recently the number of these observations has substantially increased, but there is a lack of information on the mechanistic issues in stem cell plasticity. In three different models for skin, liver and skeletal muscle plasticity, we have shown that following transplantation of the marrow cells from green fluorescent protein (GFP) transgenic mice, high levels of conversion of marrow cells can be identified. Injury to the tissue was the single most important factor for this phenomenon since the incidence of marrow to other tissue conversions significantly increased after tissue injury was implemented. Our studies also demonstrate the effect of radiation on the extent of marrow conversion.

Original languageEnglish (US)
Pages (from-to)42-46
Number of pages5
JournalBlood Cells, Molecules, and Diseases
Volume32
Issue number1
DOIs
StatePublished - Jan 2004
Externally publishedYes

Keywords

  • Marrow stem cell
  • Muscle regeneration
  • Transplantation

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine
  • Hematology

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    Abedi, M., Greer, D. A., Colvin, G. A., Demers, D. A., Dooner, M. S., Harpel, J. A., Pimentel, J., Menon, M. K., & Quesenberry, P. J. (2004). Tissue injury in marrow transdifferentiation. Blood Cells, Molecules, and Diseases, 32(1), 42-46. https://doi.org/10.1016/j.bcmd.2003.09.026