TY - JOUR
T1 - Tissue engineering the cardiac microenvironment
T2 - Multicellular microphysiological systems for drug screening
AU - Kurokawa, Yosuke K.
AU - George, Steven
PY - 2016/1/15
Y1 - 2016/1/15
N2 - The ability to accurately detect cardiotoxicity has become increasingly important in the development of new drugs. Since the advent of human pluripotent stem cell-derived cardiomyocytes, researchers have explored their use in creating an in vitro drug screening platform. Recently, there has been increasing interest in creating 3D microphysiological models of the heart as a tool to detect cardiotoxic compounds. By recapitulating the complex microenvironment that exists in the native heart, cardiac microphysiological systems have the potential to provide a more accurate pharmacological response compared to current standards in preclinical drug screening. This review aims to provide an overview on the progress made in creating advanced models of the human heart, including the significance and contributions of the various cellular and extracellular components to cardiac function.
AB - The ability to accurately detect cardiotoxicity has become increasingly important in the development of new drugs. Since the advent of human pluripotent stem cell-derived cardiomyocytes, researchers have explored their use in creating an in vitro drug screening platform. Recently, there has been increasing interest in creating 3D microphysiological models of the heart as a tool to detect cardiotoxic compounds. By recapitulating the complex microenvironment that exists in the native heart, cardiac microphysiological systems have the potential to provide a more accurate pharmacological response compared to current standards in preclinical drug screening. This review aims to provide an overview on the progress made in creating advanced models of the human heart, including the significance and contributions of the various cellular and extracellular components to cardiac function.
KW - 3D tissue
KW - Cardiotoxicity
KW - In vitro drug screening
KW - Stem cell-derived cardiomyocyte
UR - http://www.scopus.com/inward/record.url?scp=84951854898&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84951854898&partnerID=8YFLogxK
U2 - 10.1016/j.addr.2015.07.004
DO - 10.1016/j.addr.2015.07.004
M3 - Review article
C2 - 26212156
AN - SCOPUS:84951854898
VL - 96
SP - 225
EP - 233
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
SN - 0169-409X
ER -