Tissue engineering the cardiac microenvironment: Multicellular microphysiological systems for drug screening

Yosuke K. Kurokawa, Steven George

Research output: Contribution to journalReview article

26 Scopus citations

Abstract

The ability to accurately detect cardiotoxicity has become increasingly important in the development of new drugs. Since the advent of human pluripotent stem cell-derived cardiomyocytes, researchers have explored their use in creating an in vitro drug screening platform. Recently, there has been increasing interest in creating 3D microphysiological models of the heart as a tool to detect cardiotoxic compounds. By recapitulating the complex microenvironment that exists in the native heart, cardiac microphysiological systems have the potential to provide a more accurate pharmacological response compared to current standards in preclinical drug screening. This review aims to provide an overview on the progress made in creating advanced models of the human heart, including the significance and contributions of the various cellular and extracellular components to cardiac function.

Original languageEnglish (US)
Pages (from-to)225-233
Number of pages9
JournalAdvanced Drug Delivery Reviews
Volume96
DOIs
StatePublished - Jan 15 2016
Externally publishedYes

Keywords

  • 3D tissue
  • Cardiotoxicity
  • In vitro drug screening
  • Stem cell-derived cardiomyocyte

ASJC Scopus subject areas

  • Pharmaceutical Science

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