Tissue Engineering in Oral and Maxillofacial Surgery

Patrick Spicer, Simon Young, F. Kurtis Kasper, Kyriacos A. Athanasiou, Antonios G. Mikos, Mark Eu-Kien Wong

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


The oral and maxillofacial region is a highly complex area composed of multiple tissue types including the facial bones, special sense organs, lining and covering tissues, a rich neural and vascular network and teeth. Trauma, developmental deformities and pathological lesions affecting this region can cause a significant loss of tissue integrity and continuity requiring considerable reconstructive procedures. While the field of tissue engineering has made significant progress in regenerating several types of oral and maxillofacial tissues both in vitro and in animal models, significant challenges remain before these techniques are embraced as a feasible clinical modality. This chapter will describe the special challenges posed by oral and maxillofacial reconstruction, outline existing reconstructive techniques and limitations, and review current tissue-engineering strategies that may be relevant. By continuing to characterize the mechanisms underlying both the normal function and pathological degradation of oral and maxillofacial structures, improved tissue-engineering constructs can be designed with the unique local environment of this region in mind.

Original languageEnglish (US)
Title of host publicationPrinciples of Tissue Engineering: Fourth Edition
PublisherElsevier Inc.
Number of pages20
ISBN (Print)9780123983589
StatePublished - Nov 2013


  • Animal models
  • Bone tissue engineering
  • Cartilage tissue engineering
  • Craniofacial tissue engineering
  • Mandibular defects
  • Maxillary defects
  • Oral and maxillofacial surgery
  • Oral mucosa tissue engineering
  • Oral mucosal defects
  • Temporomandibular joint

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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