Abstract
A new concept based on a glue has proved to be capable of binding the proteins present in the cartilage to the materials used for tissue reconstruction or regeneration. Cartilage serves to support mechanical loads and facilitate movements in moveable joints. A new approach to cartilage regeneration depends on an adhesive agent as an intermediary that can chemically bind both the native tissue and the material used to fill the defect. Functionalized chondroitin sulphate is one of the components of native cartilage, with two distinct organic moieties, and these aldehydes form a covalent bond with the native cartilage tissue to bind with the biomaterials. The tissue primer provides a strong mechanical bond to the native cartilage, and dose not damage the cells delivered through the biomaterial or the native cartilage. The new concept is expected to be applicable to orthopaedic tissue repair and in some cases in which separate tissues are required to be adhered.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 327-328 |
| Number of pages | 2 |
| Journal | Nature Materials |
| Volume | 6 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jan 1 2007 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Chemistry(all)
- Materials Science(all)
- Condensed Matter Physics
- Mechanics of Materials
- Mechanical Engineering
Cite this
Tissue Engineering : A glue for biomaterials. / Mooney, David J.; Silva, Eduardo.
In: Nature Materials, Vol. 6, No. 5, 01.01.2007, p. 327-328.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Tissue Engineering
T2 - A glue for biomaterials
AU - Mooney, David J.
AU - Silva, Eduardo
PY - 2007/1/1
Y1 - 2007/1/1
N2 - A new concept based on a glue has proved to be capable of binding the proteins present in the cartilage to the materials used for tissue reconstruction or regeneration. Cartilage serves to support mechanical loads and facilitate movements in moveable joints. A new approach to cartilage regeneration depends on an adhesive agent as an intermediary that can chemically bind both the native tissue and the material used to fill the defect. Functionalized chondroitin sulphate is one of the components of native cartilage, with two distinct organic moieties, and these aldehydes form a covalent bond with the native cartilage tissue to bind with the biomaterials. The tissue primer provides a strong mechanical bond to the native cartilage, and dose not damage the cells delivered through the biomaterial or the native cartilage. The new concept is expected to be applicable to orthopaedic tissue repair and in some cases in which separate tissues are required to be adhered.
AB - A new concept based on a glue has proved to be capable of binding the proteins present in the cartilage to the materials used for tissue reconstruction or regeneration. Cartilage serves to support mechanical loads and facilitate movements in moveable joints. A new approach to cartilage regeneration depends on an adhesive agent as an intermediary that can chemically bind both the native tissue and the material used to fill the defect. Functionalized chondroitin sulphate is one of the components of native cartilage, with two distinct organic moieties, and these aldehydes form a covalent bond with the native cartilage tissue to bind with the biomaterials. The tissue primer provides a strong mechanical bond to the native cartilage, and dose not damage the cells delivered through the biomaterial or the native cartilage. The new concept is expected to be applicable to orthopaedic tissue repair and in some cases in which separate tissues are required to be adhered.
UR - http://www.scopus.com/inward/record.url?scp=34247850783&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34247850783&partnerID=8YFLogxK
U2 - 10.1038/nmat1896
DO - 10.1038/nmat1896
M3 - Review article
VL - 6
SP - 327
EP - 328
JO - Nature Materials
JF - Nature Materials
SN - 1476-1122
IS - 5
ER -