Tissue-engineered tracheal transplantation

Silvia Baiguera, Martin A. Birchall, Paolo MacChiarini

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Regenerative medicine offers new tools with which to tackle disorders for which there is currently no good therapeutic option. The trachea is an ideal organ in which to explore the clinical potential of tissue engineering because severe large airway disease is poorly managed by conventional treatments, and the success of a graft is determined only by its ability to conduct air lifelong: that is, whether it can become a sustainable biological conduit. We define the component parts of tissue engineering and review the experimental methods used to produce airway implants to date, including a recent successful, first-in-man experience.

Original languageEnglish (US)
Pages (from-to)485-491
Number of pages7
JournalTransplantation
Volume89
Issue number5
DOIs
StatePublished - Mar 2010
Externally publishedYes

Fingerprint

Tissue Engineering
Transplantation
Regenerative Medicine
Trachea
Air
Transplants
Therapeutics

Keywords

  • Acellular matrix
  • Allogeneic human trachea
  • Autologous human cells
  • Clinical transplantation
  • Recellularization

ASJC Scopus subject areas

  • Transplantation

Cite this

Baiguera, S., Birchall, M. A., & MacChiarini, P. (2010). Tissue-engineered tracheal transplantation. Transplantation, 89(5), 485-491. https://doi.org/10.1097/TP.0b013e3181cd4ad3

Tissue-engineered tracheal transplantation. / Baiguera, Silvia; Birchall, Martin A.; MacChiarini, Paolo.

In: Transplantation, Vol. 89, No. 5, 03.2010, p. 485-491.

Research output: Contribution to journalArticle

Baiguera, S, Birchall, MA & MacChiarini, P 2010, 'Tissue-engineered tracheal transplantation', Transplantation, vol. 89, no. 5, pp. 485-491. https://doi.org/10.1097/TP.0b013e3181cd4ad3
Baiguera S, Birchall MA, MacChiarini P. Tissue-engineered tracheal transplantation. Transplantation. 2010 Mar;89(5):485-491. https://doi.org/10.1097/TP.0b013e3181cd4ad3
Baiguera, Silvia ; Birchall, Martin A. ; MacChiarini, Paolo. / Tissue-engineered tracheal transplantation. In: Transplantation. 2010 ; Vol. 89, No. 5. pp. 485-491.
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