Tissue-engineered tracheal transplantation

Silvia Baiguera, Martin A. Birchall, Paolo MacChiarini

Research output: Contribution to journalArticle

76 Scopus citations

Abstract

Regenerative medicine offers new tools with which to tackle disorders for which there is currently no good therapeutic option. The trachea is an ideal organ in which to explore the clinical potential of tissue engineering because severe large airway disease is poorly managed by conventional treatments, and the success of a graft is determined only by its ability to conduct air lifelong: that is, whether it can become a sustainable biological conduit. We define the component parts of tissue engineering and review the experimental methods used to produce airway implants to date, including a recent successful, first-in-man experience.

Original languageEnglish (US)
Pages (from-to)485-491
Number of pages7
JournalTransplantation
Volume89
Issue number5
DOIs
StatePublished - Mar 2010
Externally publishedYes

Keywords

  • Acellular matrix
  • Allogeneic human trachea
  • Autologous human cells
  • Clinical transplantation
  • Recellularization

ASJC Scopus subject areas

  • Transplantation

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  • Cite this

    Baiguera, S., Birchall, M. A., & MacChiarini, P. (2010). Tissue-engineered tracheal transplantation. Transplantation, 89(5), 485-491. https://doi.org/10.1097/TP.0b013e3181cd4ad3