TY - JOUR
T1 - Tissue engineered platforms for studying primary and metastatic neoplasm behavior in bone
AU - Thai, Victoria L.
AU - Griffin, Katherine H.
AU - Thorpe, Steven W.
AU - Randall, R. Lor
AU - Leach, J. Kent
N1 - Funding Information:
This work was supported by the National Institutes of Health under award number R01 DE025475 and R01 DE025899 (JKL). VLT was supported by the NHLBI Training Program in Basic and Translational Cardiovascular Science (T32 HL086350). This work was supported in part by NIH Training Grant (T32 GM136559) to KHG. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
PY - 2021/1/22
Y1 - 2021/1/22
N2 - Cancer is the second leading cause of death in the United States, claiming more than 560,000 lives each year. Osteosarcoma (OS) is the most common primary malignant tumor of bone in children and young adults, while bone is a common site of metastasis for tumors initiating from other tissues. The heterogeneity, continual evolution, and complexity of this disease at different stages of tumor progression drives a critical need for physiologically relevant models that capture the dynamic cancer microenvironment and advance chemotherapy techniques. Monolayer cultures have been favored for cell-based research for decades due to their simplicity and scalability. However, the nature of these models makes it impossible to fully describe the biomechanical and biochemical cues present in 3-dimensional (3D) microenvironments, such as ECM stiffness, degradability, surface topography, and adhesivity. Biomaterials have emerged as valuable tools to model the behavior of various cancers by creating highly tunable 3D systems for studying neoplasm behavior, screening chemotherapeutic drugs, and developing novel treatment delivery techniques. This review highlights the recent application of biomaterials toward the development of tumor models, details methods for their tunability, and discusses the clinical and therapeutic applications of these systems.
AB - Cancer is the second leading cause of death in the United States, claiming more than 560,000 lives each year. Osteosarcoma (OS) is the most common primary malignant tumor of bone in children and young adults, while bone is a common site of metastasis for tumors initiating from other tissues. The heterogeneity, continual evolution, and complexity of this disease at different stages of tumor progression drives a critical need for physiologically relevant models that capture the dynamic cancer microenvironment and advance chemotherapy techniques. Monolayer cultures have been favored for cell-based research for decades due to their simplicity and scalability. However, the nature of these models makes it impossible to fully describe the biomechanical and biochemical cues present in 3-dimensional (3D) microenvironments, such as ECM stiffness, degradability, surface topography, and adhesivity. Biomaterials have emerged as valuable tools to model the behavior of various cancers by creating highly tunable 3D systems for studying neoplasm behavior, screening chemotherapeutic drugs, and developing novel treatment delivery techniques. This review highlights the recent application of biomaterials toward the development of tumor models, details methods for their tunability, and discusses the clinical and therapeutic applications of these systems.
KW - 3D tumor model
KW - Biomaterials
KW - Cancer therapy
KW - Mechanical properties
KW - Tumor microenvironment
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U2 - 10.1016/j.jbiomech.2020.110189
DO - 10.1016/j.jbiomech.2020.110189
M3 - Review article
AN - SCOPUS:85098527032
VL - 115
JO - Journal of Biomechanics
JF - Journal of Biomechanics
SN - 0021-9290
M1 - 110189
ER -