Tissue distribution of surfactant proteins A and D in the mouse

Jennifer Akiyama, Ari Hoffman, Cynthia Brown, Lennell Allen, Jess Edmondson, Francis R Poulain, Samuel Hawgood

Research output: Contribution to journalArticlepeer-review

82 Scopus citations

Abstract

Surfactant proteins A and D, collagen-like lectins (collectins), were first isolated from the lung. In the lung, SP-A and SP-D have roles in surfactant homeostasis and innate immunity. In this study we show that SP-A and SP-D mRNA can be detected in a significant number of non-pulmonary tissues but the proteins have a more limited distribution. SP-D protein was detected in lung, uterus, ovary, and lacrimal gland, whereas SP-A protein was detected only in the lung. The results suggest that SP-D participates in mucosal immunity throughout the body.

Original languageEnglish (US)
Pages (from-to)993-996
Number of pages4
JournalJournal of Histochemistry and Cytochemistry
Volume50
Issue number7
StatePublished - 2002
Externally publishedYes

Keywords

  • Collectins
  • Innate immunity
  • Surfactant proteins

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

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