Tissue distribution of surfactant proteins A and D in the mouse

Jennifer Akiyama, Ari Hoffman, Cynthia Brown, Lennell Allen, Jess Edmondson, Francis R Poulain, Samuel Hawgood

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Surfactant proteins A and D, collagen-like lectins (collectins), were first isolated from the lung. In the lung, SP-A and SP-D have roles in surfactant homeostasis and innate immunity. In this study we show that SP-A and SP-D mRNA can be detected in a significant number of non-pulmonary tissues but the proteins have a more limited distribution. SP-D protein was detected in lung, uterus, ovary, and lacrimal gland, whereas SP-A protein was detected only in the lung. The results suggest that SP-D participates in mucosal immunity throughout the body.

Original languageEnglish (US)
Pages (from-to)993-996
Number of pages4
JournalJournal of Histochemistry and Cytochemistry
Volume50
Issue number7
StatePublished - 2002
Externally publishedYes

Fingerprint

Pulmonary Surfactant-Associated Protein D
Pulmonary Surfactant-Associated Protein A
Tissue Distribution
Lung
Lacrimal Apparatus
Mucosal Immunity
Lectins
Innate Immunity
Surface-Active Agents
Uterus
Ovary
Proteins
Homeostasis
Collagen
Messenger RNA

Keywords

  • Collectins
  • Innate immunity
  • Surfactant proteins

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

Cite this

Akiyama, J., Hoffman, A., Brown, C., Allen, L., Edmondson, J., Poulain, F. R., & Hawgood, S. (2002). Tissue distribution of surfactant proteins A and D in the mouse. Journal of Histochemistry and Cytochemistry, 50(7), 993-996.

Tissue distribution of surfactant proteins A and D in the mouse. / Akiyama, Jennifer; Hoffman, Ari; Brown, Cynthia; Allen, Lennell; Edmondson, Jess; Poulain, Francis R; Hawgood, Samuel.

In: Journal of Histochemistry and Cytochemistry, Vol. 50, No. 7, 2002, p. 993-996.

Research output: Contribution to journalArticle

Akiyama, J, Hoffman, A, Brown, C, Allen, L, Edmondson, J, Poulain, FR & Hawgood, S 2002, 'Tissue distribution of surfactant proteins A and D in the mouse', Journal of Histochemistry and Cytochemistry, vol. 50, no. 7, pp. 993-996.
Akiyama J, Hoffman A, Brown C, Allen L, Edmondson J, Poulain FR et al. Tissue distribution of surfactant proteins A and D in the mouse. Journal of Histochemistry and Cytochemistry. 2002;50(7):993-996.
Akiyama, Jennifer ; Hoffman, Ari ; Brown, Cynthia ; Allen, Lennell ; Edmondson, Jess ; Poulain, Francis R ; Hawgood, Samuel. / Tissue distribution of surfactant proteins A and D in the mouse. In: Journal of Histochemistry and Cytochemistry. 2002 ; Vol. 50, No. 7. pp. 993-996.
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