Tissue culture studies of Schwann cell proliferation and differentiation

David E Pleasure, B. Kreidner, S. Shuman, G. Sobue

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Neonatal rat sciatic nerve Schwann cells in monolayer culture are stimulated to proliferate and to express a lipid and a protein characteristic of myelin by agents which raise intracellular cyclic adenosine 3',5'-monophosphate. Both glial growth factor and axolemmal fragments increase the rate of mitosis of cultured rat and human Schwann cells. Rat Schwann cell mitosis is enhanced by a soluble factor produced by concanavalin A-stimulated blood mononuclear cells and inhibited by lead salts. Schwann-like cells cultured from human dermal and plexiform neurofibromas resemble normal human Schwann cells in phenotype and response to mitogens.

Original languageEnglish (US)
Pages (from-to)364-374
Number of pages11
JournalDevelopmental Neuroscience
Volume7
Issue number5-6
StatePublished - 1985
Externally publishedYes

Fingerprint

Schwann Cells
Cell Differentiation
Cell Proliferation
Mitosis
Plexiform Neurofibroma
Neuregulin-1
Myelin Proteins
Sciatic Nerve
Concanavalin A
Mitogens
Cyclic AMP
Blood Cells
Salts
Phenotype
Lipids
Neurons
Skin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Tissue culture studies of Schwann cell proliferation and differentiation. / Pleasure, David E; Kreidner, B.; Shuman, S.; Sobue, G.

In: Developmental Neuroscience, Vol. 7, No. 5-6, 1985, p. 364-374.

Research output: Contribution to journalArticle

Pleasure, DE, Kreidner, B, Shuman, S & Sobue, G 1985, 'Tissue culture studies of Schwann cell proliferation and differentiation', Developmental Neuroscience, vol. 7, no. 5-6, pp. 364-374.
Pleasure, David E ; Kreidner, B. ; Shuman, S. ; Sobue, G. / Tissue culture studies of Schwann cell proliferation and differentiation. In: Developmental Neuroscience. 1985 ; Vol. 7, No. 5-6. pp. 364-374.
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