Tissue culture studies of Schwann cell proliferation and differentiation

David E Pleasure, B. Kreidner, S. Shuman, G. Sobue

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Neonatal rat sciatic nerve Schwann cells in monolayer culture are stimulated to proliferate and to express a lipid and a protein characteristic of myelin by agents which raise intracellular cyclic adenosine 3',5'-monophosphate. Both glial growth factor and axolemmal fragments increase the rate of mitosis of cultured rat and human Schwann cells. Rat Schwann cell mitosis is enhanced by a soluble factor produced by concanavalin A-stimulated blood mononuclear cells and inhibited by lead salts. Schwann-like cells cultured from human dermal and plexiform neurofibromas resemble normal human Schwann cells in phenotype and response to mitogens.

Original languageEnglish (US)
Pages (from-to)364-374
Number of pages11
JournalDevelopmental Neuroscience
Issue number5-6
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)


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