Tissue ablation using high-intensity focused ultrasound in the fetal sheep model: Potential for fetal treatment

Bettina W. Paek, Shahram Vaezy, Vic Fujimoto, Michael Bailey, Craig T. Albanese, Michael R. Harrison, Diana L Farmer

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

OBJECTIVE: The aim of this study was to investigate the efficacy of high-intensity focused ultrasound (HIFU) ablation of fetal tissue in a sheep model. HIFU can deliver large amounts of thermal energy by using ultrasonic waves to induce tissue necrosis, without damaging intervening tissues. In contrast to diagnostic ultrasound where intensity levels are below 0.1 W/cm 2, HIFU can deliver 1,000 to 10,000 W/cm2 at the focal spot. STUDY DESIGN: A protocol for HIFU-induced tissue coagulation in the fetus was developed in the ovine model. The fetal liver, lung, kidney, muscle, and placenta were targets for ultrasound-guided tissue ablation by a HIFU beam. All lesions were assessed macroscopically and by histologic analysis. RESULTS: In all animals, a necrotic lesion, similar in size to the HIFU focus (approximately 1 x 9 mm), was achieved. The fetal heart rate remained stable immediately after the procedure. CONCLUSION: In conclusion, HIFU ablation seems to be an effective means to coagulate even highly vascularized tissues in the fetus. This procedure shows promise as a transcutaneous, minimally invasive technique to decrease blood flow through fetal tumors or vascular anastomoses. We are currently conducting further studies to refine the HIFU technique and assess safety for fetus and mother.

Original languageEnglish (US)
Pages (from-to)702-705
Number of pages4
JournalAmerican Journal of Obstetrics and Gynecology
Volume189
Issue number3
DOIs
StatePublished - Sep 1 2003

Fingerprint

High-Intensity Focused Ultrasound Ablation
Sheep
Fetus
Therapeutics
Fetal Heart Rate
Placenta
Blood Vessels
Ultrasonography
Necrosis
Hot Temperature
Kidney
Safety
Muscles
Lung
Liver
Neoplasms

Keywords

  • Fetus
  • High-intensity focused ultrasound
  • Noninvasive
  • Sheep model
  • Tissue ablation

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Tissue ablation using high-intensity focused ultrasound in the fetal sheep model : Potential for fetal treatment. / Paek, Bettina W.; Vaezy, Shahram; Fujimoto, Vic; Bailey, Michael; Albanese, Craig T.; Harrison, Michael R.; Farmer, Diana L.

In: American Journal of Obstetrics and Gynecology, Vol. 189, No. 3, 01.09.2003, p. 702-705.

Research output: Contribution to journalArticle

Paek, Bettina W. ; Vaezy, Shahram ; Fujimoto, Vic ; Bailey, Michael ; Albanese, Craig T. ; Harrison, Michael R. ; Farmer, Diana L. / Tissue ablation using high-intensity focused ultrasound in the fetal sheep model : Potential for fetal treatment. In: American Journal of Obstetrics and Gynecology. 2003 ; Vol. 189, No. 3. pp. 702-705.
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