Tip47: A cargo selection device for mannose 6-phosphate receptor trafficking

Elva D Diaz, Suzanne R. Pfeffer

Research output: Contribution to journalArticle

307 Scopus citations

Abstract

Mannose 6-phosphate receptors (MPRs) transport newly synthesized lysosomal hydrolases from the Golgi to prelysosomes and then return to the Golgi for another round of transport. We have identified a 47 kDa protein (TIP47) that binds selectivity to the cytoplasmic domains of cation- independent and cation-dependent MPRs. TIP47 is present in cytosol and on endosomes and is required for MPR transport from endosomes to the trans- Golgi network in vitro and in vivo. TIP47 recognizes a phenylalanine/tryptophan signal in the tail of the cation-dependent MPR that is essential for its proper sorting within the endosomal pathway. These data suggest that TIP47 binds MPR cytoplasmic domains and facilitates their collection into transport vesicles destined for the Golgi.

Original languageEnglish (US)
Pages (from-to)433-443
Number of pages11
JournalCell
Volume93
Issue number3
DOIs
StatePublished - May 1 1998
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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