TIN-PROTOPORPHYRIN AND LONG WAVE LENGTH ULTRAVIOLET LIGHT IN TREATMENT OF PSORIASIS

Lennart Emtestam, Bo Angelin, Lars Berglund, GeorgeS Drummond, Attallah Kappas

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

To assess the effects of tin (Sn)-protoporphyrin (a synthetic haem analogue) in conjunction with long wave length ultraviolet light (UVA) radiation in psoriasis 10 patients, 9 of whom were substantially or completely unresponsive to other forms of therapy, received 2·0 μmol/kg bodyweight of Sn-protoporphyrin for 1 day followed by UVA light treatment for 21 days. The average starting UVA dose was 5·6 (SD 2·0) J/cm2, and the average cumulative UVA dose was 98·3 (35·1) J/cm2. Severity of psoriatic plaques, scored clinically on a scale of 0-3 for erythema, scaling, and induration, fell from a mean score of 7·9 at the start of the study to 3·6 at the end. Psoriatic lesions were improved in all patients and the effect was striking in some. The responses lasted throughout the three weeks of the study and no deleterious side-effects of the treatment were noted. Clinical follow-up for three months showed no rebound in disease activity. Sn-protoporphyrin with conventional UVA light may be useful in the treatment of psoriasis.

Original languageEnglish (US)
Pages (from-to)1231-1233
Number of pages3
JournalThe Lancet
Volume333
Issue number8649
DOIs
StatePublished - Jun 3 1989
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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