Timing of Cyclic Estradiol Treatment Differentially Affects Cognition in Aged Female Rhesus Monkeys

Mark G. Baxter, Anthony C. Santistevan, Eliza Bliss-Moreau, John Morrison

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Some evidence suggests that there may be a limited �window of opportunity� for beneficial effects of hormone therapy after menopause in women. We tested whether the timing of cyclic estradiol (E2) treatment impacted its effect on cognitive function in aged, surgically menopausal (ovariectomized) rhesus monkeys. Monkeys were assigned to one of four treatment conditions after ovariectomy: either vehicle or E2 treatment for the duration of the protocol, vehicle for the first 2 years of the protocol followed by E2 for the remainder (delayed treatment), or E2 for the first 11 months of the protocol followed by vehicle for the remainder (withdrawn treatment). Delayed treatment addressed the hypothesis that E2 treatment initiated more than 2 years postovariectomy would have a reduced effect on cognitive function. Withdrawn treatment mirrored current clinical advice to women to use hormone therapy in the initial postmenopausal period then discontinue it. Two periods of cognitive testing assessed treatment effects on cognition over time. E2 treatment predominantly affected a prefrontal cortexdependent test of spatiotemporal working memory (delayed response). Monkeys with delayed E2 treatment modestly improved in delayed response performance over time, whereas vehicle-treated monkeys declined. Monkeys with withdrawn E2 treatment maintained their performance across assessments, as did monkeys treated with E2 across the entire protocol. These findings suggest that a �window of opportunity� for hormone treatment after cessation of ovarian function, if present in nonhuman primates, lasts longer than 2 years. They also support the notion that beneficial effects of hormone therapy may persist after discontinuation of treatment.

Original languageEnglish (US)
JournalBehavioral Neuroscience
DOIs
StateAccepted/In press - Jun 28 2018

Fingerprint

Macaca mulatta
Cognition
Estradiol
Haplorhini
Therapeutics
Hormones
Postmenopause
Withholding Treatment
Ovariectomy
Clinical Protocols
Menopause
Short-Term Memory
Primates

Keywords

  • Aging
  • Estrogen
  • Macaque
  • Prefrontal
  • Working memory

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Timing of Cyclic Estradiol Treatment Differentially Affects Cognition in Aged Female Rhesus Monkeys. / Baxter, Mark G.; Santistevan, Anthony C.; Bliss-Moreau, Eliza; Morrison, John.

In: Behavioral Neuroscience, 28.06.2018.

Research output: Contribution to journalArticle

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