Timing is everything: cell cycle control of Rad52

Jacqueline Barlow, Rodney Rothstein

Research output: Contribution to journalComment/debate

15 Citations (Scopus)

Abstract

Regulation of the repair of DNA double-strand breaks by homologous recombination is extremely important for both cell viability and the maintenance of genomic integrity. Modulation of double-strand break repair in the yeast Saccharomyces cerevisiae involves controlling the recruitment of one of the central recombination proteins, Rad52, to sites of DNA lesions. The Rad52 protein, which plays a role in strand exchange and the annealing of single strand DNA, is positively regulated upon entry into S phase, repressed during the intra-S phase checkpoint, and undergoes posttranslational modification events such as phosphorylation and sumoylation. These processes all contribute to the timing of Rad52 recruitment, its stability and function. Here, we summarize the regulatory events affecting the Rad52 protein and discuss how this regulation impacts DNA repair and cell survival.

Original languageEnglish (US)
Article number7
JournalCell Division
Volume5
DOIs
StatePublished - Feb 23 2010
Externally publishedYes

Fingerprint

Rad52 DNA Repair and Recombination Protein
S Phase Cell Cycle Checkpoints
Cell Cycle Checkpoints
Cells
Repair
DNA
Cell Survival
Yeast
Sumoylation
Double-Stranded DNA Breaks
Homologous Recombination
Post Translational Protein Processing
S Phase
DNA Repair
Genetic Recombination
Phosphorylation
Saccharomyces cerevisiae
Yeasts
Maintenance
Modulation

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Timing is everything : cell cycle control of Rad52. / Barlow, Jacqueline; Rothstein, Rodney.

In: Cell Division, Vol. 5, 7, 23.02.2010.

Research output: Contribution to journalComment/debate

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