Abstract
The effects of time before feeding and dose of dietary-limiting amino acids (DLAA) injected into the prepyriform cortex (PPC) on intake of amino acid-imbalanced diets were evaluated. Intake of imbalanced diet was increased from ∼50% to ∼75% of baseline when an optimal amount of DLAA (1 nmol l-isoleucine or 2 nmol l-threonine) was injected immediately prior to feeding. Injections made several hours prior to feeding were more effective, increasing intake of imbalanced diets to ∼85% of baseline. Delivering two half-optimal doses of DLAA,several hours apart, increased intake of imbalanced diet only to the same level as a single injection of the optimal dose immediately prior to feeding. The increase in intake of a threonine-imbalanced diet after injecting 2 nmol threonine 6 h prior to feeding was abolished if an additional 2 nmol threonine was injected immediately prior to feeding. It appears that it is the sum of the changes in tissue DLAA concentrations in the PPC that are recognized and influence food intake when amino acid imbalanced diets are fed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 899-903 |
| Number of pages | 5 |
| Journal | Physiology and Behavior |
| Volume | 53 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jan 1 1993 |
| Externally published | Yes |
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Keywords
- Amino acid imbalance
- Food intake
- Prepyriform cortex
- rats
ASJC Scopus subject areas
- Experimental and Cognitive Psychology
- Behavioral Neuroscience
Cite this
Timing and dose of amino acids injected into prepyriform cortex influence food intake. / Beverly, J. Lee; Hrupka, Brian J.; Gietzen, Dorothy W.; Rogers, Quinton.
In: Physiology and Behavior, Vol. 53, No. 5, 01.01.1993, p. 899-903.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Timing and dose of amino acids injected into prepyriform cortex influence food intake
AU - Beverly, J. Lee
AU - Hrupka, Brian J.
AU - Gietzen, Dorothy W.
AU - Rogers, Quinton
PY - 1993/1/1
Y1 - 1993/1/1
N2 - The effects of time before feeding and dose of dietary-limiting amino acids (DLAA) injected into the prepyriform cortex (PPC) on intake of amino acid-imbalanced diets were evaluated. Intake of imbalanced diet was increased from ∼50% to ∼75% of baseline when an optimal amount of DLAA (1 nmol l-isoleucine or 2 nmol l-threonine) was injected immediately prior to feeding. Injections made several hours prior to feeding were more effective, increasing intake of imbalanced diets to ∼85% of baseline. Delivering two half-optimal doses of DLAA,several hours apart, increased intake of imbalanced diet only to the same level as a single injection of the optimal dose immediately prior to feeding. The increase in intake of a threonine-imbalanced diet after injecting 2 nmol threonine 6 h prior to feeding was abolished if an additional 2 nmol threonine was injected immediately prior to feeding. It appears that it is the sum of the changes in tissue DLAA concentrations in the PPC that are recognized and influence food intake when amino acid imbalanced diets are fed.
AB - The effects of time before feeding and dose of dietary-limiting amino acids (DLAA) injected into the prepyriform cortex (PPC) on intake of amino acid-imbalanced diets were evaluated. Intake of imbalanced diet was increased from ∼50% to ∼75% of baseline when an optimal amount of DLAA (1 nmol l-isoleucine or 2 nmol l-threonine) was injected immediately prior to feeding. Injections made several hours prior to feeding were more effective, increasing intake of imbalanced diets to ∼85% of baseline. Delivering two half-optimal doses of DLAA,several hours apart, increased intake of imbalanced diet only to the same level as a single injection of the optimal dose immediately prior to feeding. The increase in intake of a threonine-imbalanced diet after injecting 2 nmol threonine 6 h prior to feeding was abolished if an additional 2 nmol threonine was injected immediately prior to feeding. It appears that it is the sum of the changes in tissue DLAA concentrations in the PPC that are recognized and influence food intake when amino acid imbalanced diets are fed.
KW - Amino acid imbalance
KW - Food intake
KW - Prepyriform cortex
KW - rats
UR - http://www.scopus.com/inward/record.url?scp=0027156778&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027156778&partnerID=8YFLogxK
U2 - 10.1016/0031-9384(93)90266-I
DO - 10.1016/0031-9384(93)90266-I
M3 - Article
C2 - 8511205
AN - SCOPUS:0027156778
VL - 53
SP - 899
EP - 903
JO - Physiology and Behavior
JF - Physiology and Behavior
SN - 0031-9384
IS - 5
ER -