Abstract
The aim of this work is to develop a platform for characterizing extracellular vesicles (EV) by using gold-polymer nanopillar SERS arrays simultaneously circumventing the photoluminescence-related disadvantages of Raman with a time-resolved approach. EVs are rich of biochemical information reporting of, for example, diseased state of the biological system. Currently, straightforward, label-free and fast EV characterization methods with low sample consumption are warranted. In this study, SERS spectra of red blood cell and platelet derived EVs were successfully measured and their biochemical contents analyzed using multivariate data analysis techniques. The developed platform could be conveniently used for EV analytics in general.
Original language | English (US) |
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Title of host publication | Plasmonics in Biology and Medicine XIV |
Publisher | SPIE |
Volume | 10080 |
ISBN (Electronic) | 9781510606012 |
DOIs | |
State | Published - 2017 |
Externally published | Yes |
Event | Plasmonics in Biology and Medicine XIV - San Francisco, United States Duration: Jan 30 2017 → … |
Other
Other | Plasmonics in Biology and Medicine XIV |
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Country | United States |
City | San Francisco |
Period | 1/30/17 → … |
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Radiology Nuclear Medicine and imaging