Time-resolved SERS for characterizing extracellular vesicles

Tatu Rojalin, Heikki Saari, Petter Somersalo, Saara Laitinen, Mikko Turunen, Tapani Viitala, Sebastian Wachsmann-Hogiu, Zachary J. Smith, Marjo Yliperttula

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The aim of this work is to develop a platform for characterizing extracellular vesicles (EV) by using gold-polymer nanopillar SERS arrays simultaneously circumventing the photoluminescence-related disadvantages of Raman with a time-resolved approach. EVs are rich of biochemical information reporting of, for example, diseased state of the biological system. Currently, straightforward, label-free and fast EV characterization methods with low sample consumption are warranted. In this study, SERS spectra of red blood cell and platelet derived EVs were successfully measured and their biochemical contents analyzed using multivariate data analysis techniques. The developed platform could be conveniently used for EV analytics in general.

Original languageEnglish (US)
Title of host publicationPlasmonics in Biology and Medicine XIV
PublisherSPIE
Volume10080
ISBN (Electronic)9781510606012
DOIs
StatePublished - 2017
Externally publishedYes
EventPlasmonics in Biology and Medicine XIV - San Francisco, United States
Duration: Jan 30 2017 → …

Other

OtherPlasmonics in Biology and Medicine XIV
CountryUnited States
CitySan Francisco
Period1/30/17 → …

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Time-resolved SERS for characterizing extracellular vesicles'. Together they form a unique fingerprint.

  • Cite this

    Rojalin, T., Saari, H., Somersalo, P., Laitinen, S., Turunen, M., Viitala, T., Wachsmann-Hogiu, S., Smith, Z. J., & Yliperttula, M. (2017). Time-resolved SERS for characterizing extracellular vesicles. In Plasmonics in Biology and Medicine XIV (Vol. 10080). [100800U] SPIE. https://doi.org/10.1117/12.2271865