Time-resolved fluorescence spectroscopy of human brain tumors

Laura Marcu, Reid C. Thompson, Smita Garde, Mark Sedrak, Keith L. Black, William H. Yong

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Scopus citations


Fluorescence spectroscopy of the endogenous emission of brain tumors has been researched as a potentially important method for the intraoperative localization of brain tumor margins. In this study, we investigate the use of time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) for demarcation of primary brain tumors by studying the time-resolved spectra of gliomas of different histologic grades. Time-resolved fluorescence (3 ns, 337 nm excitation) from excised human brain tumor show differences between the time-resolved emission of malignant glioma and normal brain tissue (gray and white matter). Our findings suggest that brain tumors can be differentiated from normal brain tissue based upon unique time-resolved fluorescence signature.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
Number of pages5
StatePublished - 2002
EventOptical Biopsy IV - San Jose, CA, United States
Duration: Jan 21 2002Jan 23 2002


OtherOptical Biopsy IV
Country/TerritoryUnited States
CitySan Jose, CA


  • Brain tumor
  • Glioma
  • Spectroscopy
  • Time-resolved laser induced fluorescence

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics


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