Time-domain laser-induced fluorescence spectroscopy apparatus for clinical diagnostics

Qiyin Fang, Thanassis Papaioannou, Javier A. Jo, Russel Vaitha, Kumar Shastry, Laura Marcu

Research output: Contribution to journalArticle

116 Scopus citations

Abstract

The design and development of a compact optical fiber-based apparatus for in situ time-resolved laser-induced fluorescence spectroscopy of biological systems was described. The apparatus allows direct recording of the entire fluorescence decay with high sensitivity. It was observed that the apparatus is modular, optically robust, and compatible with the clinical environment. It was found that the apparatus provides both time-resolved and spectrally resolved fluorescence emission information of the sample in less than 0.8 s per wavelength and with good dynamic range and sensitivity.

Original languageEnglish (US)
Pages (from-to)151-162
Number of pages12
JournalReview of Scientific Instruments
Volume75
Issue number1
DOIs
StatePublished - Jan 2004

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ASJC Scopus subject areas

  • Instrumentation
  • Physics and Astronomy (miscellaneous)

Cite this

Fang, Q., Papaioannou, T., Jo, J. A., Vaitha, R., Shastry, K., & Marcu, L. (2004). Time-domain laser-induced fluorescence spectroscopy apparatus for clinical diagnostics. Review of Scientific Instruments, 75(1), 151-162. https://doi.org/10.1063/1.1634354