Time-domain laser-induced fluorescence spectroscopy apparatus for clinical diagnostics

Qiyin Fang, Thanassis Papaioannou, Javier A. Jo, Russel Vaitha, Kumar Shastry, Laura Marcu

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

The design and development of a compact optical fiber-based apparatus for in situ time-resolved laser-induced fluorescence spectroscopy of biological systems was described. The apparatus allows direct recording of the entire fluorescence decay with high sensitivity. It was observed that the apparatus is modular, optically robust, and compatible with the clinical environment. It was found that the apparatus provides both time-resolved and spectrally resolved fluorescence emission information of the sample in less than 0.8 s per wavelength and with good dynamic range and sensitivity.

Original languageEnglish (US)
Pages (from-to)151-162
Number of pages12
JournalReview of Scientific Instruments
Volume75
Issue number1
DOIs
StatePublished - Jan 2004

Fingerprint

Fluorescence spectroscopy
laser induced fluorescence
Fluorescence
Lasers
Biological systems
spectroscopy
Optical fibers
Wavelength
fluorescence
sensitivity
dynamic range
optical fibers
recording
decay
wavelengths

ASJC Scopus subject areas

  • Instrumentation
  • Physics and Astronomy (miscellaneous)

Cite this

Fang, Q., Papaioannou, T., Jo, J. A., Vaitha, R., Shastry, K., & Marcu, L. (2004). Time-domain laser-induced fluorescence spectroscopy apparatus for clinical diagnostics. Review of Scientific Instruments, 75(1), 151-162. https://doi.org/10.1063/1.1634354

Time-domain laser-induced fluorescence spectroscopy apparatus for clinical diagnostics. / Fang, Qiyin; Papaioannou, Thanassis; Jo, Javier A.; Vaitha, Russel; Shastry, Kumar; Marcu, Laura.

In: Review of Scientific Instruments, Vol. 75, No. 1, 01.2004, p. 151-162.

Research output: Contribution to journalArticle

Fang, Q, Papaioannou, T, Jo, JA, Vaitha, R, Shastry, K & Marcu, L 2004, 'Time-domain laser-induced fluorescence spectroscopy apparatus for clinical diagnostics', Review of Scientific Instruments, vol. 75, no. 1, pp. 151-162. https://doi.org/10.1063/1.1634354
Fang, Qiyin ; Papaioannou, Thanassis ; Jo, Javier A. ; Vaitha, Russel ; Shastry, Kumar ; Marcu, Laura. / Time-domain laser-induced fluorescence spectroscopy apparatus for clinical diagnostics. In: Review of Scientific Instruments. 2004 ; Vol. 75, No. 1. pp. 151-162.
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