Abstract
Although circadian rhythms have been described for many human functions, there are minimal data on circadian rhythms related to skin physiology. This study investigated the circadian rhythmicity of skin variables related to skin barrier function in humans. We measured transepidermal water loss, stratum corneum moisture, skin surface pH, and skin temperature in 16 healthy volunteers (nine men and seven women, aged 23-53 y). Subjects were sampled every 2 h in two sessions over a 24 h span. Twelve samples were obtained for each variable in the following sites: forehead, forearm, upper back, and shin. We used cosinor analysis and ANOVA to validate observed differences. Time-dependent rhythms were detected in most skin variables except in stratum corneum hydration. We found a statistically significant circadian rhythmicity characterized by cosinor analysis in transepidermal water loss, skin surface pH, and skin temperature on the forearm, forehead, and shin. Peak-trough differences occurred in all locations. The values of the same variables measured at different sites correlated positively, whereas the values of the different variables did not. These results suggest that skin permeability is higher in the evening and night than in the morning. These data may be clinically relevant in several aspects applied to skin physiology and topical drug application.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 20-23 |
| Number of pages | 4 |
| Journal | Journal of Investigative Dermatology |
| Volume | 110 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1998 |
| Externally published | Yes |
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Keywords
- Circadian rhythms
- Cosinor analysis
- Skin physiology
ASJC Scopus subject areas
- Dermatology
Cite this
Time-dependent variations of the skin barrier function in humans : Transepidermal water loss, stratum corneum hydration, skin surface pH, and skin temperature. / Yosipovitch, G.; Xiong, Glen; Haus, E.; Sackett-Lundeen, L.; Ashkenazi, I.; Maibach, H. I.
In: Journal of Investigative Dermatology, Vol. 110, No. 1, 1998, p. 20-23.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Time-dependent variations of the skin barrier function in humans
T2 - Transepidermal water loss, stratum corneum hydration, skin surface pH, and skin temperature
AU - Yosipovitch, G.
AU - Xiong, Glen
AU - Haus, E.
AU - Sackett-Lundeen, L.
AU - Ashkenazi, I.
AU - Maibach, H. I.
PY - 1998
Y1 - 1998
N2 - Although circadian rhythms have been described for many human functions, there are minimal data on circadian rhythms related to skin physiology. This study investigated the circadian rhythmicity of skin variables related to skin barrier function in humans. We measured transepidermal water loss, stratum corneum moisture, skin surface pH, and skin temperature in 16 healthy volunteers (nine men and seven women, aged 23-53 y). Subjects were sampled every 2 h in two sessions over a 24 h span. Twelve samples were obtained for each variable in the following sites: forehead, forearm, upper back, and shin. We used cosinor analysis and ANOVA to validate observed differences. Time-dependent rhythms were detected in most skin variables except in stratum corneum hydration. We found a statistically significant circadian rhythmicity characterized by cosinor analysis in transepidermal water loss, skin surface pH, and skin temperature on the forearm, forehead, and shin. Peak-trough differences occurred in all locations. The values of the same variables measured at different sites correlated positively, whereas the values of the different variables did not. These results suggest that skin permeability is higher in the evening and night than in the morning. These data may be clinically relevant in several aspects applied to skin physiology and topical drug application.
AB - Although circadian rhythms have been described for many human functions, there are minimal data on circadian rhythms related to skin physiology. This study investigated the circadian rhythmicity of skin variables related to skin barrier function in humans. We measured transepidermal water loss, stratum corneum moisture, skin surface pH, and skin temperature in 16 healthy volunteers (nine men and seven women, aged 23-53 y). Subjects were sampled every 2 h in two sessions over a 24 h span. Twelve samples were obtained for each variable in the following sites: forehead, forearm, upper back, and shin. We used cosinor analysis and ANOVA to validate observed differences. Time-dependent rhythms were detected in most skin variables except in stratum corneum hydration. We found a statistically significant circadian rhythmicity characterized by cosinor analysis in transepidermal water loss, skin surface pH, and skin temperature on the forearm, forehead, and shin. Peak-trough differences occurred in all locations. The values of the same variables measured at different sites correlated positively, whereas the values of the different variables did not. These results suggest that skin permeability is higher in the evening and night than in the morning. These data may be clinically relevant in several aspects applied to skin physiology and topical drug application.
KW - Circadian rhythms
KW - Cosinor analysis
KW - Skin physiology
UR - http://www.scopus.com/inward/record.url?scp=0031951231&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031951231&partnerID=8YFLogxK
U2 - 10.1046/j.1523-1747.1998.00069.x
DO - 10.1046/j.1523-1747.1998.00069.x
M3 - Article
C2 - 9424081
AN - SCOPUS:0031951231
VL - 110
SP - 20
EP - 23
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
SN - 0022-202X
IS - 1
ER -