Time course of serum amyloid A response in myocardial infarction

Linda L. Bausserman, Ara Sadaniantz, Ann L. Saritelli, Virginia L. Martin, Anne M. Nugent, Stanley P. Sady, Peter N. Herbert

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Plasma concentrations of serum amyloid A (SAA), high density lipoprotein (HDL) cholesterol, non-HDL cholesterol, and apolipoproteins (Apo) A-I and B were measured daily for 6 days in 10 patients following myocardial infarction (MI) and in 10 secular controls admitted to a coronary care unit. SAA concentrations peaked 3 days following MI (mean 47 mg/dl) and correlated with creatine kinase (CK) (r = 0.67, P < 0.001). Non-HDL cholesterol and Apo B fell 15 and 18%, respectively, reached nadirs 3-4 days after MI and were inversely related to CK concentrations (P <0.01 for both). HDL cholesterol levels, in contrast, increased 15% and were significantly higher than baseline by day 3 when SAA concentrations were maximum. HDL cholesterol subsequently fell in parallel with SAA and had returned to baseline by day 6. Apo A-I declined throughout the 6 days of observation and was 13% lower than initial values on day 6 (P < 0.05). The Apo A-I reduction was inversely related to both CK and SAA concentrations. There were no significant changes in any of the analytes in control subjects. We conclude that Apo A-I and possibly Apo B containing lipoproteins are negative acute phase reactants. HDL cholesterol is transiently elevated after MI despite decreasing Apo A-I levels and this may relate to incorporation of SAA into HDL particles.

Original languageEnglish (US)
Pages (from-to)297-305
Number of pages9
JournalClinica Chimica Acta
Volume184
Issue number3
DOIs
StatePublished - Oct 16 1989
Externally publishedYes

Keywords

  • Acute phase response
  • Lipoprotein
  • Myocardial infarction
  • Serum amyloid A

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry

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    Bausserman, L. L., Sadaniantz, A., Saritelli, A. L., Martin, V. L., Nugent, A. M., Sady, S. P., & Herbert, P. N. (1989). Time course of serum amyloid A response in myocardial infarction. Clinica Chimica Acta, 184(3), 297-305. https://doi.org/10.1016/0009-8981(89)90063-6