Time course of early delayed blood-brain barrier changes in individual cats after lonizing radiation

Michael P. Remler, William H. Marcussen

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Cats were given 6000 rads to a volume of approximately 0.25 cm3 and followed for blood-brain barrier (B-BB) breakdown by the penicillin-EEG method. They showed a variation of about 1 to 20 days before the onset of B-BB breakdown and of 20 to 80 days for recovery. This demonstrates the central role of endothelium damage and loss of B-BB function in the pathogenesis of radiation damage to the central nervous system.

Original languageEnglish (US)
Pages (from-to)310-314
Number of pages5
JournalExperimental Neurology
Volume73
Issue number1
DOIs
StatePublished - 1981

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology

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