Abstract
Cats were given 6000 rads to a volume of approximately 0.25 cm3 and followed for blood-brain barrier (B-BB) breakdown by the penicillin-EEG method. They showed a variation of about 1 to 20 days before the onset of B-BB breakdown and of 20 to 80 days for recovery. This demonstrates the central role of endothelium damage and loss of B-BB function in the pathogenesis of radiation damage to the central nervous system.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 310-314 |
| Number of pages | 5 |
| Journal | Experimental Neurology |
| Volume | 73 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1981 |
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ASJC Scopus subject areas
- Neuroscience(all)
- Neurology
Cite this
Time course of early delayed blood-brain barrier changes in individual cats after lonizing radiation. / Remler, Michael P.; Marcussen, William H.
In: Experimental Neurology, Vol. 73, No. 1, 1981, p. 310-314.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Time course of early delayed blood-brain barrier changes in individual cats after lonizing radiation
AU - Remler, Michael P.
AU - Marcussen, William H.
PY - 1981
Y1 - 1981
N2 - Cats were given 6000 rads to a volume of approximately 0.25 cm3 and followed for blood-brain barrier (B-BB) breakdown by the penicillin-EEG method. They showed a variation of about 1 to 20 days before the onset of B-BB breakdown and of 20 to 80 days for recovery. This demonstrates the central role of endothelium damage and loss of B-BB function in the pathogenesis of radiation damage to the central nervous system.
AB - Cats were given 6000 rads to a volume of approximately 0.25 cm3 and followed for blood-brain barrier (B-BB) breakdown by the penicillin-EEG method. They showed a variation of about 1 to 20 days before the onset of B-BB breakdown and of 20 to 80 days for recovery. This demonstrates the central role of endothelium damage and loss of B-BB function in the pathogenesis of radiation damage to the central nervous system.
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U2 - 10.1016/0014-4886(81)90065-0
DO - 10.1016/0014-4886(81)90065-0
M3 - Article
VL - 73
SP - 310
EP - 314
JO - Experimental Neurology
JF - Experimental Neurology
SN - 0014-4886
IS - 1
ER -