Time course of early delayed blood-brain barrier changes in individual cats after lonizing radiation

Michael P. Remler; William H. Marcussen

doi:10.1016/0014-4886(81)90065-0

Time course of early delayed blood-brain barrier changes in individual cats after lonizing radiation

Michael P. Remler, William H. Marcussen

Neurology

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Cats were given 6000 rads to a volume of approximately 0.25 cm³ and followed for blood-brain barrier (B-BB) breakdown by the penicillin-EEG method. They showed a variation of about 1 to 20 days before the onset of B-BB breakdown and of 20 to 80 days for recovery. This demonstrates the central role of endothelium damage and loss of B-BB function in the pathogenesis of radiation damage to the central nervous system.

Original language	English (US)
Pages (from-to)	310-314
Number of pages	5
Journal	Experimental Neurology
Volume	73
Issue number	1
DOIs	https://doi.org/10.1016/0014-4886(81)90065-0
State	Published - 1981

ASJC Scopus subject areas

Neuroscience(all)
Neurology

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abstract = "Cats were given 6000 rads to a volume of approximately 0.25 cm3 and followed for blood-brain barrier (B-BB) breakdown by the penicillin-EEG method. They showed a variation of about 1 to 20 days before the onset of B-BB breakdown and of 20 to 80 days for recovery. This demonstrates the central role of endothelium damage and loss of B-BB function in the pathogenesis of radiation damage to the central nervous system.",

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