Time course and effective sites for inhibition from midbrain periaqueductal gray of spinal dorsal horn neuronal responses to cutaneous stimuli in the cat

Earl Carstens, D. Klumpp, M. Zimmermann

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Inhibition of spinal dorsal horn neuronal responses to noxious (50 °C) skin heating by stimulation of the midbrain periaqueductal gray (PAG) was quantitatively investigated in cats anesthetized with sodium pentobarbital and nitrous oxide. Systematic variation of the interval between onset of PAG stimulation (PAGS) and onset of noxious skin heating revealed that a marked reduction of spinal unit heat-evoked discharges occured immediately upon onset of PAGS, and ceased immediately at offset of PAGS with a post-stimulation excitatory rebound. Stimulation at sites in both ventral and dorsal PAG produced inhibition, the strength of which increased sometimes in a linear manner with increasing strength of PAGS. Thresholds for the generation of descending inhibition were higher in dorsal than ventral PAG. PAGS also inhibited spinal unit responses to non-noxious skin stimulation (brushing of hairs). Descending inhibition from PAG is considered as a possible mechanism for analgesia produced by stimulation of PAG and other brainstem structures.

Original languageEnglish (US)
Pages (from-to)425-430
Number of pages6
JournalExperimental Brain Research
Volume38
Issue number4
DOIs
StatePublished - Mar 1980
Externally publishedYes

Fingerprint

Periaqueductal Gray
Mesencephalon
Cats
Skin
Heating
Nitrous Oxide
Pentobarbital
Hair
Analgesia
Brain Stem
Spinal Cord Dorsal Horn
Hot Temperature

Keywords

  • Analgesia
  • Descending inhibition
  • Noxious heat
  • Periaqueductal gray
  • Spinal dorsal horn

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Time course and effective sites for inhibition from midbrain periaqueductal gray of spinal dorsal horn neuronal responses to cutaneous stimuli in the cat. / Carstens, Earl; Klumpp, D.; Zimmermann, M.

In: Experimental Brain Research, Vol. 38, No. 4, 03.1980, p. 425-430.

Research output: Contribution to journalArticle

@article{4e65fa094f384535972a7dd4e6f8883f,
title = "Time course and effective sites for inhibition from midbrain periaqueductal gray of spinal dorsal horn neuronal responses to cutaneous stimuli in the cat",
abstract = "Inhibition of spinal dorsal horn neuronal responses to noxious (50 °C) skin heating by stimulation of the midbrain periaqueductal gray (PAG) was quantitatively investigated in cats anesthetized with sodium pentobarbital and nitrous oxide. Systematic variation of the interval between onset of PAG stimulation (PAGS) and onset of noxious skin heating revealed that a marked reduction of spinal unit heat-evoked discharges occured immediately upon onset of PAGS, and ceased immediately at offset of PAGS with a post-stimulation excitatory rebound. Stimulation at sites in both ventral and dorsal PAG produced inhibition, the strength of which increased sometimes in a linear manner with increasing strength of PAGS. Thresholds for the generation of descending inhibition were higher in dorsal than ventral PAG. PAGS also inhibited spinal unit responses to non-noxious skin stimulation (brushing of hairs). Descending inhibition from PAG is considered as a possible mechanism for analgesia produced by stimulation of PAG and other brainstem structures.",
keywords = "Analgesia, Descending inhibition, Noxious heat, Periaqueductal gray, Spinal dorsal horn",
author = "Earl Carstens and D. Klumpp and M. Zimmermann",
year = "1980",
month = "3",
doi = "10.1007/BF00237522",
language = "English (US)",
volume = "38",
pages = "425--430",
journal = "Experimental Brain Research",
issn = "0014-4819",
publisher = "Springer Verlag",
number = "4",

}

TY - JOUR

T1 - Time course and effective sites for inhibition from midbrain periaqueductal gray of spinal dorsal horn neuronal responses to cutaneous stimuli in the cat

AU - Carstens, Earl

AU - Klumpp, D.

AU - Zimmermann, M.

PY - 1980/3

Y1 - 1980/3

N2 - Inhibition of spinal dorsal horn neuronal responses to noxious (50 °C) skin heating by stimulation of the midbrain periaqueductal gray (PAG) was quantitatively investigated in cats anesthetized with sodium pentobarbital and nitrous oxide. Systematic variation of the interval between onset of PAG stimulation (PAGS) and onset of noxious skin heating revealed that a marked reduction of spinal unit heat-evoked discharges occured immediately upon onset of PAGS, and ceased immediately at offset of PAGS with a post-stimulation excitatory rebound. Stimulation at sites in both ventral and dorsal PAG produced inhibition, the strength of which increased sometimes in a linear manner with increasing strength of PAGS. Thresholds for the generation of descending inhibition were higher in dorsal than ventral PAG. PAGS also inhibited spinal unit responses to non-noxious skin stimulation (brushing of hairs). Descending inhibition from PAG is considered as a possible mechanism for analgesia produced by stimulation of PAG and other brainstem structures.

AB - Inhibition of spinal dorsal horn neuronal responses to noxious (50 °C) skin heating by stimulation of the midbrain periaqueductal gray (PAG) was quantitatively investigated in cats anesthetized with sodium pentobarbital and nitrous oxide. Systematic variation of the interval between onset of PAG stimulation (PAGS) and onset of noxious skin heating revealed that a marked reduction of spinal unit heat-evoked discharges occured immediately upon onset of PAGS, and ceased immediately at offset of PAGS with a post-stimulation excitatory rebound. Stimulation at sites in both ventral and dorsal PAG produced inhibition, the strength of which increased sometimes in a linear manner with increasing strength of PAGS. Thresholds for the generation of descending inhibition were higher in dorsal than ventral PAG. PAGS also inhibited spinal unit responses to non-noxious skin stimulation (brushing of hairs). Descending inhibition from PAG is considered as a possible mechanism for analgesia produced by stimulation of PAG and other brainstem structures.

KW - Analgesia

KW - Descending inhibition

KW - Noxious heat

KW - Periaqueductal gray

KW - Spinal dorsal horn

UR - http://www.scopus.com/inward/record.url?scp=0018838359&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018838359&partnerID=8YFLogxK

U2 - 10.1007/BF00237522

DO - 10.1007/BF00237522

M3 - Article

C2 - 7363975

AN - SCOPUS:0018838359

VL - 38

SP - 425

EP - 430

JO - Experimental Brain Research

JF - Experimental Brain Research

SN - 0014-4819

IS - 4

ER -