Thyroid hormone receptor mutations in cancer and resistance to thyroid hormone

Perspective and prognosis

Meghan D. Rosen, Martin L. Privalsky

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Thyroid hormone, operating through its receptors, plays crucial roles in the control of normal human physiology and development; deviations from the norm can give rise to disease. Clinical endocrinologists often must confront and correct the consequences of inappropriately high or low thyroid hormone synthesis. Although more rare, disruptions in thyroid hormone endocrinology due to aberrations in the receptor also have severe medical consequences. This review will focus on the afflictions that are caused by, or are closely associated with, mutated thyroid hormone receptors. These include Resistance to Thyroid Hormone Syndrome, erythroleukemia, hepatocellular carcinoma, renal clear cell carcinoma, and thyroid cancer. We will describe current views on the molecular bases of these diseases, and what distinguishes the neoplastic from the non-neoplastic. We will also touch on studies that implicate alterations in receptor expression, and thyroid hormone levels, in certain oncogenic processes. opyright

Original languageEnglish (US)
Article number361304
JournalJournal of Thyroid Research
Volume2011
DOIs
StatePublished - 2011

Fingerprint

Thyroid Hormone Resistance Syndrome
Thyroid Hormone Receptors
Thyroid Hormones
Mutation
Neoplasms
Leukemia, Erythroblastic, Acute
Endocrinology
Human Development
Thyroid Neoplasms
Renal Cell Carcinoma
Hepatocellular Carcinoma

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Thyroid hormone receptor mutations in cancer and resistance to thyroid hormone : Perspective and prognosis. / Rosen, Meghan D.; Privalsky, Martin L.

In: Journal of Thyroid Research, Vol. 2011, 361304, 2011.

Research output: Contribution to journalArticle

@article{f1496b96aeaa455c8eecf587f1f38642,
title = "Thyroid hormone receptor mutations in cancer and resistance to thyroid hormone: Perspective and prognosis",
abstract = "Thyroid hormone, operating through its receptors, plays crucial roles in the control of normal human physiology and development; deviations from the norm can give rise to disease. Clinical endocrinologists often must confront and correct the consequences of inappropriately high or low thyroid hormone synthesis. Although more rare, disruptions in thyroid hormone endocrinology due to aberrations in the receptor also have severe medical consequences. This review will focus on the afflictions that are caused by, or are closely associated with, mutated thyroid hormone receptors. These include Resistance to Thyroid Hormone Syndrome, erythroleukemia, hepatocellular carcinoma, renal clear cell carcinoma, and thyroid cancer. We will describe current views on the molecular bases of these diseases, and what distinguishes the neoplastic from the non-neoplastic. We will also touch on studies that implicate alterations in receptor expression, and thyroid hormone levels, in certain oncogenic processes. opyright",
author = "Rosen, {Meghan D.} and Privalsky, {Martin L.}",
year = "2011",
doi = "10.4061/2011/361304",
language = "English (US)",
volume = "2011",
journal = "Journal of Thyroid Research",
issn = "2090-8067",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Thyroid hormone receptor mutations in cancer and resistance to thyroid hormone

T2 - Perspective and prognosis

AU - Rosen, Meghan D.

AU - Privalsky, Martin L.

PY - 2011

Y1 - 2011

N2 - Thyroid hormone, operating through its receptors, plays crucial roles in the control of normal human physiology and development; deviations from the norm can give rise to disease. Clinical endocrinologists often must confront and correct the consequences of inappropriately high or low thyroid hormone synthesis. Although more rare, disruptions in thyroid hormone endocrinology due to aberrations in the receptor also have severe medical consequences. This review will focus on the afflictions that are caused by, or are closely associated with, mutated thyroid hormone receptors. These include Resistance to Thyroid Hormone Syndrome, erythroleukemia, hepatocellular carcinoma, renal clear cell carcinoma, and thyroid cancer. We will describe current views on the molecular bases of these diseases, and what distinguishes the neoplastic from the non-neoplastic. We will also touch on studies that implicate alterations in receptor expression, and thyroid hormone levels, in certain oncogenic processes. opyright

AB - Thyroid hormone, operating through its receptors, plays crucial roles in the control of normal human physiology and development; deviations from the norm can give rise to disease. Clinical endocrinologists often must confront and correct the consequences of inappropriately high or low thyroid hormone synthesis. Although more rare, disruptions in thyroid hormone endocrinology due to aberrations in the receptor also have severe medical consequences. This review will focus on the afflictions that are caused by, or are closely associated with, mutated thyroid hormone receptors. These include Resistance to Thyroid Hormone Syndrome, erythroleukemia, hepatocellular carcinoma, renal clear cell carcinoma, and thyroid cancer. We will describe current views on the molecular bases of these diseases, and what distinguishes the neoplastic from the non-neoplastic. We will also touch on studies that implicate alterations in receptor expression, and thyroid hormone levels, in certain oncogenic processes. opyright

UR - http://www.scopus.com/inward/record.url?scp=84867947390&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867947390&partnerID=8YFLogxK

U2 - 10.4061/2011/361304

DO - 10.4061/2011/361304

M3 - Article

VL - 2011

JO - Journal of Thyroid Research

JF - Journal of Thyroid Research

SN - 2090-8067

M1 - 361304

ER -