Abstract
Thyroid hormone, operating through its receptors, plays crucial roles in the control of normal human physiology and development; deviations from the norm can give rise to disease. Clinical endocrinologists often must confront and correct the consequences of inappropriately high or low thyroid hormone synthesis. Although more rare, disruptions in thyroid hormone endocrinology due to aberrations in the receptor also have severe medical consequences. This review will focus on the afflictions that are caused by, or are closely associated with, mutated thyroid hormone receptors. These include Resistance to Thyroid Hormone Syndrome, erythroleukemia, hepatocellular carcinoma, renal clear cell carcinoma, and thyroid cancer. We will describe current views on the molecular bases of these diseases, and what distinguishes the neoplastic from the non-neoplastic. We will also touch on studies that implicate alterations in receptor expression, and thyroid hormone levels, in certain oncogenic processes. opyright
| Original language | English (US) |
|---|---|
| Article number | 361304 |
| Journal | Journal of Thyroid Research |
| Volume | 2011 |
| DOIs | |
| State | Published - 2011 |
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ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
Cite this
Thyroid hormone receptor mutations in cancer and resistance to thyroid hormone : Perspective and prognosis. / Rosen, Meghan D.; Privalsky, Martin L.
In: Journal of Thyroid Research, Vol. 2011, 361304, 2011.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Thyroid hormone receptor mutations in cancer and resistance to thyroid hormone
T2 - Perspective and prognosis
AU - Rosen, Meghan D.
AU - Privalsky, Martin L.
PY - 2011
Y1 - 2011
N2 - Thyroid hormone, operating through its receptors, plays crucial roles in the control of normal human physiology and development; deviations from the norm can give rise to disease. Clinical endocrinologists often must confront and correct the consequences of inappropriately high or low thyroid hormone synthesis. Although more rare, disruptions in thyroid hormone endocrinology due to aberrations in the receptor also have severe medical consequences. This review will focus on the afflictions that are caused by, or are closely associated with, mutated thyroid hormone receptors. These include Resistance to Thyroid Hormone Syndrome, erythroleukemia, hepatocellular carcinoma, renal clear cell carcinoma, and thyroid cancer. We will describe current views on the molecular bases of these diseases, and what distinguishes the neoplastic from the non-neoplastic. We will also touch on studies that implicate alterations in receptor expression, and thyroid hormone levels, in certain oncogenic processes. opyright
AB - Thyroid hormone, operating through its receptors, plays crucial roles in the control of normal human physiology and development; deviations from the norm can give rise to disease. Clinical endocrinologists often must confront and correct the consequences of inappropriately high or low thyroid hormone synthesis. Although more rare, disruptions in thyroid hormone endocrinology due to aberrations in the receptor also have severe medical consequences. This review will focus on the afflictions that are caused by, or are closely associated with, mutated thyroid hormone receptors. These include Resistance to Thyroid Hormone Syndrome, erythroleukemia, hepatocellular carcinoma, renal clear cell carcinoma, and thyroid cancer. We will describe current views on the molecular bases of these diseases, and what distinguishes the neoplastic from the non-neoplastic. We will also touch on studies that implicate alterations in receptor expression, and thyroid hormone levels, in certain oncogenic processes. opyright
UR - http://www.scopus.com/inward/record.url?scp=84867947390&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84867947390&partnerID=8YFLogxK
U2 - 10.4061/2011/361304
DO - 10.4061/2011/361304
M3 - Article
C2 - 21760978
AN - SCOPUS:84867947390
VL - 2011
JO - Journal of Thyroid Research
JF - Journal of Thyroid Research
SN - 2090-8067
M1 - 361304
ER -